Tumor Classification and Its Application in Surgical Treatment of Craniopharyngioma
|The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.|
|ClinicalTrials.gov Identifier: NCT00949156|
Recruitment Status : Unknown
Verified September 2010 by Southern Medical University, China.
Recruitment status was: Active, not recruiting
First Posted : July 30, 2009
Last Update Posted : September 15, 2010
|Condition or disease||Intervention/treatment||Phase|
|Craniopharyngioma||Procedure: Different surgical approach and techniques being used to treat three subtype of CP||Phase 1|
|Study Type :||Observational|
|Estimated Enrollment :||238 participants|
|Official Title:||Tumor Classification and Its Application in Surgical Treatment of Craniopharyngioma|
|Study Start Date :||September 1997|
|Primary Completion Date :||October 2009|
|Estimated Study Completion Date :||December 2015|
The 198 cases of CP with primary surgery in our hospital (since July, 1997 until now) were divided into three topographical groups based on the pre-operative MRI, intraoperative findings and the tumor-membrane relationship. The presurgical manifestation, the different surgical approach, intraoperative techniques, and postoperative complication were described and analyzed to establish a normalized surgical treatment of individual CP patient, which has the highest rate of the totally tumoral resection and the lowest rate of the hypothalamic injury.
The anticipated 40 cases of CP were surgical treated by our standard procedure, which is recruited in the prospective cohort. With the long-term follow up, QOL including the cognition, circadian rhythm, endocrine, Water-Electrolyte, and body weight et al were evaluated to assess the rationality of the treatment. Then according to the results, the surgical treatment was modified, and the endocrinic substitution therapy was also been developed.
Procedure: Different surgical approach and techniques being used to treat three subtype of CP
According to the presurgical MRI, with the analysis of the morphological characteristic of three subtype of CP, different surgical approach and intrasurgical skills were used to treat tumors with trying to total remove tumor and avoid the hypothalamus injury.
- The course of suprasellar arachnoid mater and pia mater, and the construction of all meninges of the sellar region was observed and measured by microscopy. [ Time Frame: 1~2 years ]
- Through the analysis of the pre- and postoperative imaging and intrasurgical findings of CP, and combined considering of the tumor-membrane relationship, the classification of CP was proposed. [ Time Frame: 1~2 years ]
- After long term follow up of CP patients, the normalized treatment was evaluated and modified. [ Time Frame: 3~5 years ]
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00949156
|Neurosurgery department, Nanfang hospital|
|Guangzhou, Guangdong, China, 510515|
|Principal Investigator:||Songtao Qi, MD, PhD||Director, Neurosurgery department, Nanfang Hospital|