This site became the new on June 19th. Learn more.
Show more Menu IMPORTANT: Listing of a study on this site does not reflect endorsement by the National Institutes of Health. Talk with a trusted healthcare professional before volunteering for a study. Read more... Menu IMPORTANT: Talk with a trusted healthcare professional before volunteering for a study. Read more... Menu
Give us feedback

Evaluation of Plasma Catecholamine Concentration During Surgery

The recruitment status of this study is unknown. The completion date has passed and the status has not been verified in more than two years.
Verified July 2009 by Kliniken Essen-Mitte.
Recruitment status was:  Active, not recruiting
Universität Duisburg-Essen
Information provided by:
Kliniken Essen-Mitte Identifier:
First received: July 28, 2009
Last updated: NA
Last verified: July 2009
History: No changes posted
Stress during surgery leads to significant increase in plasma catecholamine concentrations in surgeons, anesthesiologists, and patients.


Study Type: Observational
Study Design: Observational Model: Cohort
Time Perspective: Prospective
Official Title: Evaluation of Stress Hormone Concentration During the Resection of Pheochromocytoma. Comparison of Surgeon - Anesthesiologist - Patient

Resource links provided by NLM:

Further study details as provided by Kliniken Essen-Mitte:

Biospecimen Retention:   Samples Without DNA
Venous blood will be drawn from the surgeon, anesthesiologist and from 8 patients to determine plasma catecholamine concentrations. Only plasma will be used for measurements.

Estimated Enrollment: 8
Study Start Date: June 2009
Estimated Study Completion Date: September 2010
Estimated Primary Completion Date: July 2010 (Final data collection date for primary outcome measure)
To detect the degree of intraoperative stress, venous blod will be drawn from one surgeon during 8 pheochromocytoma resections.
To detect the degree of intraoperative stress, venous blood will be drawn from one anesthesiologist during 8 pheochromocytoma resections.
Patients with pheochromocytoma
Venous blood will be drawn from 8 patients with pheochromocytoma during tumor resection.

Detailed Description:
Hypothesis: Resection of pheochromocytomas can lead to more than normal stress in surgeons and because of abrupt hemodynamic changes in patients as well in anesthesiologists. Measurements of catecholamine concentrations at baseline, prior to surgery during and after surgery, are to be performed to test this hypothesis.

Ages Eligible for Study:   18 Years and older   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population
The population consists of 8 patients with pheochromocytoma scheduled for tumor resection, one surgeon (with the experience of more than 50 pheochromocytoma resections) and one anesthesiologist (with the experience of more than 50 pheochromocytoma resections).

Inclusion Criteria: Patients with pheochromocytoma (Older than 18 years) -

Exclusion Criteria: Patients younger than 18 years. Conservative treatment.

  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its identifier: NCT00948181

Prof. Dr. Harald Groeben
Essen, Germany, 45136
Sponsors and Collaborators
Kliniken Essen-Mitte
Universität Duisburg-Essen
Principal Investigator: Harald Groeben, M.D. Kliniken Essen-Mitte
  More Information

Responsible Party: Prof. Dr. Harald Groeben, Kliniken Essen-Mitte Identifier: NCT00948181     History of Changes
Other Study ID Numbers: 2009061
Study First Received: July 28, 2009
Last Updated: July 28, 2009

Keywords provided by Kliniken Essen-Mitte:
Epinephrine, Norepinephrine, normetanephrine
Catecholamine concentrations during surgery processed this record on September 19, 2017