Impact of SSKI Pre-Treatment on Blood Loss in Thyroidectomy for Graves Disease
|Study Design:||Allocation: Randomized
Endpoint Classification: Efficacy Study
Intervention Model: Parallel Assignment
Masking: Single Blind (Investigator)
Primary Purpose: Treatment
|Official Title:||Impact of SSKI Pre-Treatment on Blood Loss in Thyroidectomy for Graves Disease|
- Blood Loss During Surgery [ Time Frame: up to 162 minutes ] [ Designated as safety issue: Yes ]Blood loss in milliliters during surgery.
|Study Start Date:||April 2005|
|Study Completion Date:||April 2013|
|Primary Completion Date:||April 2013 (Final data collection date for primary outcome measure)|
Active Comparator: Potassium Iodide
8 drops of Potassium Iodide in a glass of water, by mouth, daily for 7 days prior to operation.
Drug: Potassium Iodide
8 drops of Potassium Iodide in a glass of water taken daily for 7 days prior to thyroidectomy. This is the current standard of care.
Other Name: SSKI
No Intervention: No Treatment
The experimental group receives no treatment.
Historically Potassium Iodide was given to patients for 1 week prior to thyroidectomy. This common practice was used to decrease thyroid function and prevent thyroid storm during the thyroidectomy. However, in modern practice, nearly all patients presenting for surgical management have been made euthyroid through the use of medications such as propylthiouracil. Despite this potassium iodine continues to be administered with the presumption that it decreases the friability of the gland making surgery easier, with less blood loss.
The outcomes to be measured in this surgery are operative time, operative complications and blood loss.
Please refer to this study by its ClinicalTrials.gov identifier: NCT00946296
|United States, Massachusetts|
|UMASS Memorial Health Care|
|Worcester, Massachusetts, United States, 01655|