Cytochrome P450 2D6 (CYP 450 2D6) Genotype and Flecainide Efficacy
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ClinicalTrials.gov Identifier: NCT00945867
Verified July 2009 by Assaf-Harofeh Medical Center. Recruitment status was: Not yet recruiting
The determination of the 2D6 genotype will enable us to determine the way flecainide is metabolized by the liver. Some individuals are poor metabolizers and some individuals are extensive metabolizers of the drug. This will also determine which patients will benefit from the drug.
Condition or disease
Pharmacogenetics is the study of genetic variations on drug metabolizing enzymes and transporters. Pharmacogenetics is one of the first clinical applications of the Human Genome Project. Pharmacogenomics is the study of the role of interindividual genomics variability on drug response, efficacy, and metabolism. It correlates the effects of the entire expressed genome to the clinical usefulness and toxicity of a drug. Pharmacogenomics has the potential to change the way patients' therapy is optimized, allowing an era of "personalized medicine" in which patients will be divided into groups based on genetic markers that treatment outcomes.
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Ages Eligible for Study:
18 Years to 90 Years (Adult, Senior)
Sexes Eligible for Study:
Accepts Healthy Volunteers:
Patients with atrial fibrillation and a normal heart.
Patients with recurrent AF
Patients with a structurally normal heart
Patients > 18 YO
Patients who signed an informed consent
Renal failure with creatinine clearance less than 40
Elevated liver enzymes 3 times the normal range, or causing coagulation test abnormality