Natriuretic Peptides - Predictors of In-hospital and Long-term Major Adverse Cardiac Events After Emergency Surgery?
|The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.|
|ClinicalTrials.gov Identifier: NCT00942786|
Recruitment Status : Completed
First Posted : July 21, 2009
Results First Posted : June 29, 2015
Last Update Posted : June 29, 2015
|Condition or disease|
|Study Type :||Observational|
|Actual Enrollment :||297 participants|
|Official Title:||Prospective Study to Evaluate the Predictive Value of Brain Natriuretic Peptides for Adverse Long-term Cardiac Outcome|
|Study Start Date :||February 2008|
|Actual Primary Completion Date :||January 2014|
|Actual Study Completion Date :||February 2014|
Consecutive patients undergoing emergency surgery
- Occurence of Adverse Cardiac Events [ Time Frame: postoperatively (index surgery) until a median follow-up of 34 months ]
Occurence of major adverse cardiac events (composite of nonfatal myocardial infarction, acute heart failure or death).
Non-fatal Myocardial infarction was defined as a typical increase and decrease of troponin together with evidence of myocardial ischemia with at least one of the following: symptoms of ischemia, ECG changes indicative of ischemia or new Q waves, or imaging evidence of new regional wall motion abnormality.
Acute heart failure was defined as clinical signs and symptoms of heart failure with echocardiographic evidence of cardiac dysfunction and clinical response to treatment directed towards heart failure.
- NT-ProBNP Preoperative [ Time Frame: 0-24 hours before induction of anesthesia ]NT-ProBNP was measured 0-24 hours before induction of anesthesia
- Association Between Preoperative NT-ProBNP and Occurence of Adverse Cardiac Events [ Time Frame: postoperatively (index surgery) until a median follow-up of 34 months ]Evaluation of the association between preoperative NT-ProBNP and occurence of adverse cardiac events
Biospecimen Retention: Samples Without DNA
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00942786
|Department of Anesthesia and Intensive Care Medicine|
|Graz, Austria, 8036|
|Principal Investigator:||Elisabeth Mahla, M.D.||Department of Anesthesiology and Intensive Care Medicine, Medical University of Graz|