Central Corneal Thickness and 24-hour Fluctuation of Intraocular Pressure (CCT-IOP)
The purpose of this study is to determine whether 24-hour fluctuation of intraocular pressure (IOP) is associated with central corneal thickness (CCT) in subjects with ocular hypertension or open angle glaucoma and in age-matched controls. Also to evaluate whether mean IOP reduction as a response to latanoprost (0.005% Xalatan) is associated with CCT, after a 4-weeks period of treatment.
Also, to evaluate whether 24-hour fluctuation of IOP is associated with corneal hysteresis (CH) measured by Ocular Response Analyzer (ORA).
|Study Design:||Intervention Model: Single Group Assignment
Masking: None (Open Label)
Primary Purpose: Basic Science
|Official Title:||Central Corneal Thickness and 24-hour Fluctuation of Intraocular Pressure|
- Correlation analyses between mean central corneal thickness (CCT) and 24-hour intraocular pressure (IOP) fluctuation and between mean CCT and mean IOP reduction from baseline after a 4-weeks period of treatment with latanoprost. [ Time Frame: Before and after a 4-weeks period of treatment with latanoprost. ]
- Correlation analyses between corneal hysteresis (CH) and 24-hour intraocular pressure (IOP) fluctuation and between CH and mean IOP reduction from baseline after a 4-weeks period of treatment with latanoprost. [ Time Frame: Before and after a 4-weeks period of treatment with latanoprost. ]
|Study Start Date:||September 2009|
|Study Completion Date:||July 2014|
|Primary Completion Date:||July 2014 (Final data collection date for primary outcome measure)|
This study includes two groups.
1 eyedrop of latanoprost (0.005%) dosed once a day at 8:00pm for a 4-weeks period
Other Name: 0.005% Xalatan
Please refer to this study by its ClinicalTrials.gov identifier: NCT00941525
|A' Department of Ophthalmology, Aristotle University of Thessaloniki, AHEPA Hospital|
|Thessaloniki, Greece, 54636|
|Principal Investigator:||Fotis Topouzis, MD||Aristotle University Of Thessaloniki|