Comparison of Elution Swab (ESwab) and Amies Transport Swabs for Screening Patients for Methicillin Resistant Staphylococcus Aureus (MRSA) and Vancomycin Resistant Enterococci (VRE) Colonization (MRSA VRE)

Study Description

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Study Description Study Design Groups and Cohorts Outcome Measures Eligibility Criteria Contacts and Locations More Information

Brief Summary:

1.To assess whether the Elution swab (ESwab) is superior to Amies transport swabs for the detection of Methicillin Resistant Staphylococcus aureus (MRSA) and Vancomycin Resistant Enterococci (VRE) in colonized patients and to determine whether nasal cultures alone is sufficient for detection of MRSA isolates in hospitalized patients. 2.To assess patient comfort in the use of the ESwab vs. Amies Transport swab for screening patients for methicillin resistant Staphylococcus aureus and vancomycin-resistant Enterococcus.

Condition or disease	Intervention/treatment
Eluted Swab	Device: Eluted Swab

Detailed Description:

MRSA is a major cause of nosocomial and life threatening infections. Infections with MRSA have been associated with a significantly higher morbidity, mortality and costs than methicillin-susceptible S. aureus (MSSA).1 Selection of these organisms has been greatest in the healthcare setting; however, MRSA have also become more prevalent in the community.2 To control the transmission of MRSA, the Society for Healthcare Epidemiology of America (SHEA) has recommended guidelines, which include an active surveillance program to identify potential reservoirs and a rigorous infection control program to control the spread of MRSA. Accurate identification of patients colonized with MRSA is essential in managing the transmission of the organism. It is currently unknown whether the currently utilized collection rayon swab is the optimal swab in detecting colonized patients The purpose of this study is to directly compare whether Eluted (ESwab) swab is superior to the currently utilized rayon swab in identifying MRSA/VRE colonized patients.

Study Design

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Study Description Study Design Groups and Cohorts Outcome Measures Eligibility Criteria Contacts and Locations More Information

Study Type :	Observational
Actual Enrollment :	30 participants
Time Perspective:	Prospective
Official Title:	Comparison of Elution Swab (ESwab) and Amies Transport Swabs for Screening Patients for Methicillin Resistant Staphylococcus Aureus (MRSA) and Vancomycin Resistant Enterococci (VRE) Colonization
Study Start Date :	July 2009
Actual Primary Completion Date :	January 2011
Actual Study Completion Date :	March 2011

Groups and Cohorts

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Study Description Study Design Groups and Cohorts Outcome Measures Eligibility Criteria Contacts and Locations More Information

Group/Cohort	Intervention/treatment
MRSA/VRE patients; patients known to be colonized with MRSA/VRE	Device: Eluted Swab; Comparison of Eluted Swab with AMIES swab for detection of MRSA/VRE

Outcome Measures

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Study Description Study Design Groups and Cohorts Outcome Measures Eligibility Criteria Contacts and Locations More Information

Primary Outcome Measures :

1. 1. To assess whether the Elution swab (ESwab) is superior to Amies transport swabs for the detection of MRSA/VRE [ Time Frame: 12 months ]
2. 1. To assess whether the Elution swab (ESwab) is superior to Amies transport swabs for the detection of MRSA/VRE in colonized patients [ Time Frame: 12 months ]

Secondary Outcome Measures :

1. To assess patient comfort in the use of the ESwab vs. Amies Transport swab for screening patients for methicillin resistant Staphylococcus aureus and vancomycin-resistant Enterococcus. [ Time Frame: 12 months ]

Eligibility Criteria

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Study Description Study Design Groups and Cohorts Outcome Measures Eligibility Criteria Contacts and Locations More Information

Ages Eligible for Study:	Child, Adult, Senior
Sexes Eligible for Study:	All
Accepts Healthy Volunteers:	No
Sampling Method:	Non-Probability Sample

Study Population

Hospitalized patients known to be colonized with MRSA/VRE

Criteria

Inclusion Criteria:

• Hospitallized patients known to be colonized with MRSA/VRE

Exclusion Criteria:

• Unable to provide informed consent

Contacts and Locations

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Study Description Study Design Groups and Cohorts Outcome Measures Eligibility Criteria Contacts and Locations More Information

Locations

Canada, Ontario
St. Joseph's Healthcare
Hamilton, Ontario, Canada, L8N 4A6

Sponsors and Collaborators

Hamilton Health Sciences Corporation

McMaster University

St. Joseph's Healthcare Hamilton

Investigators

Principal Investigator:	Christine Lee, MD	McMaster University

More Information

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Study Description Study Design Groups and Cohorts Outcome Measures Eligibility Criteria Contacts and Locations More Information

Responsible Party:	Christine Lee, McMaster University
ClinicalTrials.gov Identifier:	NCT00941122 History of Changes
Other Study ID Numbers:	MRSA.VRE.Detection
First Posted:	July 17, 2009
Last Update Posted:	July 20, 2011
Last Verified:	July 2011

Keywords provided by McMaster University:

MRSA, VRE

Additional relevant MeSH terms:

Staphylococcal Infections; Gram-Positive Bacterial Infections; Bacterial Infections; Vancomycin	Methicillin; Anti-Bacterial Agents; Anti-Infective Agents