Treatment of Late-life Anxiety in Primary Care Settings

This study has been completed.
National Institute of Mental Health (NIMH)
Information provided by (Responsible Party):
Gretchen Brenes, Wake Forest Baptist Health Identifier:
First received: July 10, 2009
Last updated: June 15, 2015
Last verified: June 2015
The research study proposed is designed to examine the outcomes of a cognitive behavioral guided self-care intervention with older adults diagnosed with generalized anxiety disorder and recruited from a primary care setting. It is hypothesized that the cognitive behavioral guided self-care intervention will produce greater declines in worry and anxiety than enhanced usual care.

Condition Intervention Phase
Generalized Anxiety Disorder
Panic Disorder
Anxiety Disorder Not Otherwise Specified
Behavioral: Cognitive behavioral therapy
Behavioral: Enhanced usual care
Phase 2
Phase 3

Study Type: Interventional
Study Design: Allocation: Randomized
Endpoint Classification: Efficacy Study
Intervention Model: Parallel Assignment
Masking: Single Blind (Outcomes Assessor)
Primary Purpose: Treatment
Official Title: Treatment of Late-life Anxiety in Primary Care Settings

Resource links provided by NLM:

Further study details as provided by Wake Forest Baptist Health:

Enrollment: 60
Study Start Date: March 2006
Study Completion Date: February 2009
Primary Completion Date: February 2009 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Active Comparator: Cognitive-behavioral therapy
cognitive-behavioral therapy
Behavioral: Cognitive behavioral therapy
Participants receive 10 telephone therapy sessions and an accompanying workbook focused on cognitive-behavioral techniques for managing anxiety.
Placebo Comparator: Enhanced usual care
enhanced usual care
Behavioral: Enhanced usual care
Participants receive written information about anxiety, referrals for treatment, and an optional letter to their primary care physician.


Ages Eligible for Study:   60 Years and older
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No

Inclusion Criteria:

  • age ≥ 60 years
  • a DSM-IV diagnosis of GAD
  • able to read English.

Exclusion Criteria:

  • current psychotherapy
  • a DSM-IV diagnosis of alcohol or substance abuse
  • a diagnosis of dementia or global cognitive impairment operationalized as a score of < 24 of the Mini-Mental Status Examination
  • psychotic symptoms
  • active suicidal ideation
  Contacts and Locations
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No Contacts or Locations Provided
  More Information

Responsible Party: Gretchen Brenes, Associate Professor, Wake Forest Baptist Health Identifier: NCT00938093     History of Changes
Other Study ID Numbers: MH65281 
Study First Received: July 10, 2009
Last Updated: June 15, 2015
Health Authority: United States: Institutional Review Board

Additional relevant MeSH terms:
Anxiety Disorders
Panic Disorder
Mental Disorders
Pathologic Processes processed this record on May 03, 2016