Effectiveness of a Walking Program Modulating Cardioreparative Factors in Heart Failure (EPCCHFWalk)
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ClinicalTrials.gov Identifier: NCT00937443 |
Recruitment Status
:
Completed
First Posted
: July 13, 2009
Last Update Posted
: April 4, 2017
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Condition or disease | Intervention/treatment |
---|---|
Heart Failure | Other: Physical Fitness Biological: Walking Exercise Group |
Study Type : | Observational |
Actual Enrollment : | 9 participants |
Observational Model: | Cohort |
Time Perspective: | Prospective |
Official Title: | Effectiveness of a Walking Program Modulating Cardioreparative Factors in Heart Failure |
Actual Study Start Date : | July 2009 |
Actual Primary Completion Date : | January 2014 |
Actual Study Completion Date : | January 2014 |
Group/Cohort | Intervention/treatment |
---|---|
Walking Exercise Group
Walking Exercise Group versus Control Group
|
Other: Physical Fitness
Does intensity of aerobic walking exercise modify cardiac reparative factors
Other Name: Quality of Life Questionnaires
Biological: Walking Exercise Group
Walking Group will increase intensity, duration, and steps of walking per week.
Other Name: Quality of Life Questionnaires
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- endothelial progenitor cells [ Time Frame: 12 Weeks ]
- exercise [ Time Frame: 12 Months ]
Biospecimen Retention: Samples With DNA

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Ages Eligible for Study: | 30 Years to 65 Years (Adult) |
Sexes Eligible for Study: | All |
Accepts Healthy Volunteers: | No |
Sampling Method: | Probability Sample |
Inclusion criteria:
- Subjects 30-65 years old.
- Subjects able to give Informed Consent.
- Subjects who will give permission for collection of clinical and demographic data from the electronic medical records.
-
Subjects with symptomatic ischemic or non-ischemic heart failure in a stable condition with New York Heart Association class II-III for at least the last 3 months before study enrollment.
- Left ventricular ejection fraction (LVEF) < 40%.
- Peak volume of oxygen utilization (peak VO2) of < 25 ml/kg/min.
- Patient on a stable dose of statin or who can be initiated on statin therapy.
- Subjects with ischemic cardiomyopathy must have had either a negative stress test within the last 6 months or a cardiac catheterization within the last year confirming stable disease.
Exclusion criteria:
- Subjects with myocardial infarction or unstable angina within the last six months.
- Subjects with symptomatic or severe aortic stenosis.
- Subjects with severe HTN (SBP > 180) or hypotension (SBP < 100).
- Subjects who are pregnant.
- Subjects who have bone marrow suppression.
- Subjects with exercise limiting peripheral arterial disease.
- Subjects with history of ventricular tachycardia without an implantable defibrillator
- Subjects with decompensated diabetes (HgA1c >10).
- Subjects with orthopedic limitations.
- Subjects with any other clinical condition precluding regular participation in walking exercise regimen.
- Subjects who already participate in regular physical exercise regimen for greater than 30 minutes a day 5 days per week.

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00937443
United States, Tennessee | |
Vanderbilt Heart and Vascular Institute | |
Nashville, Tennessee, United States, 37232-8802 |
Study Director: | Douglas B Saywer, MD, PhD | Vanderbilt Heart and Vascular Institute |
Responsible Party: | Vanderbilt University Medical Center |
ClinicalTrials.gov Identifier: | NCT00937443 History of Changes |
Other Study ID Numbers: |
Vanderbilt_University |
First Posted: | July 13, 2009 Key Record Dates |
Last Update Posted: | April 4, 2017 |
Last Verified: | March 2017 |
Keywords provided by Vanderbilt University Medical Center:
Physical Activity Cardiac Heart Failure Exercise Regimen Cardioreparative Factors |
Additional relevant MeSH terms:
Heart Failure Heart Diseases Cardiovascular Diseases |