Assessment of Renal Physiology by Magnetic Resonance Imaging (MRI) in Normal Volunteers
|ClinicalTrials.gov Identifier: NCT00936416|
Recruitment Status : Completed
First Posted : July 10, 2009
Last Update Posted : January 18, 2012
Estimation of Glomerular Filtration Rate (GFR) is the primary test used to assess patients with renal disease. Although serum creatinine based GFR and nuclear medicine based estimations are routinely used in clinical practice, GFR estimation by Inulin is the recommended gold standard. Inulin based estimation of GFR is cumbersome and time consuming.
A decrease in blood flow to the kidney (Renal Blood Flow (RBF)) is known to cause a decrease in GFR. RBF is typically determined using radioactive tracers, contrast MRI or a cumbersome para-aminohippuric acid (PAH) clearance method.
MRI based assessment of GFR and RBF have been suggested to provide reasonable accuracy. Most of these studies did not compare the GFR and RBF estimation directly to Inulin and PAH clearance which are ther gold standards . In this study we propose to estimate MRI based GFR estimation directly to Inulin and noncontrast MRI based derived RBF to PAH to assess if MRI is an accurate test of kidney function.
|Condition or disease||Intervention/treatment|
|Glomerular Filtration Rate Renal Blood Flow||Procedure: Inulin and PAH clearance and MRI|
|Study Type :||Interventional (Clinical Trial)|
|Actual Enrollment :||24 participants|
|Intervention Model:||Single Group Assignment|
|Masking:||None (Open Label)|
|Official Title:||Assessment of Renal Physiology (Glomerular Filtration Rate and Blood Flow) by MRI With Validation by Inulin and Para-Aminohippuric Acid Clearance in Normal Volunteers|
|Study Start Date :||January 2010|
|Primary Completion Date :||December 2011|
|Study Completion Date :||December 2011|
Experimental: GFR and RBF followed by MRI
Subjects will undergo GFR and renal blood flow estimation by Inulin and PAH clearance method, followed by a MRI test. The MRI examination will be performed on the same day as the inulin/PAH procedure.
Procedure: Inulin and PAH clearance and MRI
GFR and renal blood flow estimation by Inulin and PAH clearance will be performed in the Renal Physiology Lab for approximately 2.5 hours;
The MRI test will be performed afterwards at Medical Imaging department and last about 45 minutes.
- GFR estimation comparison between results obtained by MRI and Inulin clearance method. Blood flow estimation comparison between results obtained by MRI and PAH clearance method. [ Time Frame: 1 year ]
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00936416
|University Health Network|
|Toronto, Ontario, Canada, M5G 2C4|
|Principal Investigator:||Kartik Jhaveri, M.D.||University Health Network, Toronto|