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Effects of Unloading on Muscle Mass

This study has been completed.
Information provided by (Responsible Party):
Maastricht University Medical Center Identifier:
First received: July 6, 2009
Last updated: July 1, 2013
Last verified: July 2013
In the present study, the effects of 3 weeks of unloading on muscle mass and muscle fiber characteristics will be determined. In addition, the effects of 6 weeks of recovery will be assessed.

Condition Intervention
Physical Inactivity
Behavioral: unloading

Study Type: Interventional
Study Design: Intervention Model: Single Group Assignment
Masking: Open Label
Primary Purpose: Basic Science
Official Title: The Effect of Immobilization on Myocellular Characteristics in Healthy, Young Males

Further study details as provided by Maastricht University Medical Center:

Primary Outcome Measures:
  • muscle mass, muscle fiber size [ Time Frame: 1 week before unloading; immediately (1 day) after unloading and 6 weeks after unloading ]

Secondary Outcome Measures:
  • muscle strength [ Time Frame: 1 week before unloading; immediately (1 day) after unloading and 6 weeks after unloading ]

Enrollment: 15
Study Start Date: October 2009
Study Completion Date: June 2013
Primary Completion Date: February 2013 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Experimental: unloading
2 weeks of unloading
Behavioral: unloading
2 weeks of unloading of a single leg


Ages Eligible for Study:   18 Years to 35 Years   (Adult)
Sexes Eligible for Study:   Male
Accepts Healthy Volunteers:   Yes

Inclusion Criteria:

  • Healthy
  • BMI < 30 kg/m2

Exclusion Criteria:

  • Use of medication that may affect haemostasis
  • Subjects with (recent) musculoskeletal/orthopaedic disorders known to affect the outcome of the study or that compromise their ability to walk with crutches
  • Subjects with metal implants in their lower limbs
  • Subjects with known cardiovascular and/or haemostasis disorders
  • Subjects with known severe hypertension
  Contacts and Locations
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Please refer to this study by its identifier: NCT00936039

Maastricht University Medical Centre
Maastricht, Netherlands, 6200MD
Sponsors and Collaborators
Maastricht University Medical Center
Principal Investigator: Luc JC van Loon, PhD Maastricht UMC
  More Information

Responsible Party: Maastricht University Medical Center Identifier: NCT00936039     History of Changes
Other Study ID Numbers: MEC-09-3-011
Study First Received: July 6, 2009
Last Updated: July 1, 2013 processed this record on May 23, 2017