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Cortisol Activity in Patients With Prader-Willi Syndrome and Healthy Controls

This study has been completed.
Information provided by:
Children's Mercy Hospital Kansas City Identifier:
First received: July 2, 2009
Last updated: June 23, 2011
Last verified: June 2011
The purpose of the study is to find out if people with Prader-Willi syndrome have a difference in the protein which changes inactive cortisone to the active stress hormone cortisol.

Prader-Willi Syndrome

Study Type: Observational
Study Design: Observational Model: Case Control
Time Perspective: Prospective
Official Title: 11 Beta Hydroxysteroid Dehydrogenase 1 (11-beta HSD 1) Activity in Patients With Prader-Willi Syndrome and in Healthy Controls

Resource links provided by NLM:

Further study details as provided by Children's Mercy Hospital Kansas City:

Estimated Enrollment: 36
Study Start Date: February 2009
Study Completion Date: August 2010
PWS not receiving Growth Hormone
Control subjects healthy or obese
PWS subjects starting Growth Hormone


Ages Eligible for Study:   6 Months and older   (Child, Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population
Defined population

Inclusion Criteria:

  • Prader-Willi syndrome confirmed by molecular testing, ages 6 months to adult
  • Controls: Age-matched, sex-matched, developmentally normal, BMI-controlled healthy or obese subjects

Exclusion Criteria:

  • PWS subjects without molecular confirmation of the diagnosis
  • Subjects receiving glucocorticoid treatment within 3 months of evaluation
  • Subjects receiving growth hormone within one year prior to analysis
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its identifier: NCT00932932

Sponsors and Collaborators
Children's Mercy Hospital Kansas City
Principal Investigator: Wayne Moore, MD Children's Mercy Hospital Kansas City
  More Information

Responsible Party: Jill Jacobson,MD, Children's Mercy Hospitals and Clinics Identifier: NCT00932932     History of Changes
Other Study ID Numbers: 09 01-014
Study First Received: July 2, 2009
Last Updated: June 23, 2011

Additional relevant MeSH terms:
Prader-Willi Syndrome
Pathologic Processes
Intellectual Disability
Neurobehavioral Manifestations
Neurologic Manifestations
Nervous System Diseases
Abnormalities, Multiple
Congenital Abnormalities
Chromosome Disorders
Genetic Diseases, Inborn
Nutrition Disorders processed this record on September 25, 2017