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Effect of Electro-Acupuncture on Blood Pressure

The recruitment status of this study is unknown. The completion date has passed and the status has not been verified in more than two years.
Verified October 2010 by University of California, Irvine.
Recruitment status was:  Recruiting
ClinicalTrials.gov Identifier:
First Posted: July 3, 2009
Last Update Posted: October 15, 2010
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
Information provided by:
University of California, Irvine
Based on previous published research in animals, the investigators hypothesize that electroacupuncture (EA) will have a positive effect on hypertension.

Condition Intervention Phase
Hypertension Arrhythmias Procedure: Electro-acupuncture Phase 1 Phase 2

Study Type: Interventional
Study Design: Allocation: Randomized
Intervention Model: Single Group Assignment
Masking: Single (Investigator)
Primary Purpose: Treatment
Official Title: Neural Mechanism of the Effect of Acupuncture on Myocardial Ischemia

Resource links provided by NLM:

Further study details as provided by University of California, Irvine:

Primary Outcome Measures:
  • Reduction in blood pressure [ Time Frame: 8 weeks ]

Secondary Outcome Measures:
  • Heart rate [ Time Frame: 8 weeks ]
  • Echocardiographic transthoracic output (CO) [ Time Frame: 8 weeks ]
  • Electrocardiogram (ECG) plasma catecholamines and renin [ Time Frame: 8 weeks ]

Estimated Enrollment: 94
Study Start Date: February 2003
Estimated Study Completion Date: December 2010
Estimated Primary Completion Date: December 2010 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Experimental: Blood Pressure
Procedure: Electro-acupuncture
First visit, blood pressure monitoring for 60 minutes at rest, then monitoring for subsequent 24 hours to measure BP and heartrate. At next 6-8 visits, Electro-acupuncture (EA) treatment for 30 minutes will be administered. BP and heart rate measurements will be taken 30 minutes before and after EA.
Other Names:
  • Blood pressure
  • Hypertension
  • Arrythmias

Detailed Description:
The purpose of this study is to prove: (1) Myocardial ischemia, cardiac arrhythmias and hypertensive response at rest and provoked by stress are decreased by EA; (2) The mechanism of the ischemic response is an imbalance between myocardial oxygen supply and demand originating as an increase in autonomic nervous system sympathetic activity causing increased oxygen demand. EA inhibits the sympathetic nervous system, decreases blood pressure and reduces the oxygen demand. Our prior data in animals shows that improvements in cardiovascular function during myocardial ischemia are mediated by an EA-induced sensory neural reflex originating in somatic nerves to reduce sympathetic nerve activity. The specific aims of the present study will allow us to better understand and modulate the sympathetic nervous discharge activity that can precipitate coronary ischemia, arrhythmias and hypertension in exercise stress in humans. Potential clinical application is the therapeutic value of EA in patients with hypertension.

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Ages Eligible for Study:   18 Years to 70 Years   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No

Inclusion Criteria:

  • Patients with mild coronary disease, and no significant ECG change reflecting ischemia at rest

Exclusion Criteria:

  • Pregnant or nursing women
  • Individuals with severe coronary disease (continuous angina)
  • Conduction abnormalities on ECG consistent with left bundle branch block
  • Cardiac arrhythmias associated with low blood pressure (90 mmHg)
  • Peripheral vascular disease
  • Orthopedic disease
  • Diabetic or psychological illness that could interfere with safe performance of exercise of psychophysiological stress testing
  • Those with known sensitivity to topical preparations or strong reactions to medical dressings and skin tapes
  Contacts and Locations
Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00932139

Contact: Peng Li, MD, LAc 949-824-6123
Contact: Sivarama Prasad Vinjamury 562-947-8755 ext 7364

United States, California
General Clinical Research Center (GCRC) Recruiting
Irvine, California, United States, 92697
Contact: Peng Li, MD, LAc    949-824-6123      
Sub-Investigator: Peng Li, MD, LAc         
Sub-Investigator: Sivarama Prasad Vinjamuary         
Sub-Investigator: Eric Hsiao, MD, PhD         
Sponsors and Collaborators
University of California, Irvine
Study Director: Peng Li, MD, LAc University of California, Irvine
Study Director: Sivarama Prasad Vinjamury Southern California University of Health Sciences
Study Director: Eric Hsiao, Md, PhD, LAc Southern California University of Health Sciences
  More Information

Responsible Party: John C Longhurst, MD, PhD, University of California Irvine
ClinicalTrials.gov Identifier: NCT00932139     History of Changes
Other Study ID Numbers: 1999-2222
First Submitted: July 1, 2009
First Posted: July 3, 2009
Last Update Posted: October 15, 2010
Last Verified: October 2010

Keywords provided by University of California, Irvine:
blood pressure
mild to moderate hypertension (145-199/90-110)

Additional relevant MeSH terms:
Vascular Diseases
Cardiovascular Diseases