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Effects of Dietary Protein on Undesirable Postprandial Events in Overweight Subjects

This study has been completed.
Sponsor:
ClinicalTrials.gov Identifier:
NCT00931151
First Posted: July 2, 2009
Last Update Posted: August 23, 2011
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
Collaborator:
National Research Agency, France
Information provided by (Responsible Party):
Robert Benamouzig, Institut National de la Recherche Agronomique
  Purpose
Dietary protein differing by their amino acid composition could modulate undesirable metabolic and functional responses to a meal rich in saturated fat and sugars. This study aims at examining the specific effects of dairy protein with different cysteine contents on the postprandial undesirables effects elicited by the ingestion of a high fat meal in overweight subjects.

Condition Intervention
Overweight Dietary Supplement: Postprandial metabolic and functional measures

Study Type: Interventional
Study Design: Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: None (Open Label)
Primary Purpose: Basic Science

Resource links provided by NLM:


Further study details as provided by Robert Benamouzig, Institut National de la Recherche Agronomique:

Primary Outcome Measures:
  • Endothelial dysfunction [ Time Frame: 0-2-4-6 hours (after meal ingestion) ]

Secondary Outcome Measures:
  • Postprandial inflammation [ Time Frame: 0-0.5-1-1.5-2-3-4-6 hours (after meal ingestion) ]

Estimated Enrollment: 10
Study Start Date: April 2009
Study Completion Date: July 2009
Primary Completion Date: July 2009 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Experimental: Casein
Protein source in the high fat meal is casein
Dietary Supplement: Postprandial metabolic and functional measures
After ingestion of a high fat meal containing the different protein sources, the subjects undergo a series of measures of endothelial dysfunction and blood and urine sampling for the assessment of proinflammatory cytokines levels and metabolomics determinations.
Experimental: Milk soluble protein
Protein source in the high fat meal are milk soluble protein
Dietary Supplement: Postprandial metabolic and functional measures
After ingestion of a high fat meal containing the different protein sources, the subjects undergo a series of measures of endothelial dysfunction and blood and urine sampling for the assessment of proinflammatory cytokines levels and metabolomics determinations.
Experimental: Alpha lactalbumin
Protein source in the high fat meal is alpha-lactalbumin
Dietary Supplement: Postprandial metabolic and functional measures
After ingestion of a high fat meal containing the different protein sources, the subjects undergo a series of measures of endothelial dysfunction and blood and urine sampling for the assessment of proinflammatory cytokines levels and metabolomics determinations.

  Eligibility

Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years to 50 Years   (Adult)
Sexes Eligible for Study:   Male
Accepts Healthy Volunteers:   Yes
Criteria

Inclusion Criteria:

  • BMI between 25 and 30
  • Waist circumference > 94 cm

Exclusion Criteria:

  • Allergy to milk protein
  • Abusive drug consumption
  • Smoking
  • Hypertension, diabetes
  • High level of physical activity
  Contacts and Locations
Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00931151


Locations
France
Centre de recherche sur volontaires
Bobigny, France, 93
Sponsors and Collaborators
Institut National de la Recherche Agronomique
National Research Agency, France
Investigators
Principal Investigator: Robert Benamouzig, MD, Ph. D Assistance Publique - Hôpitaux de Paris
  More Information

Publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number):
Responsible Party: Robert Benamouzig, Professor, Institut National de la Recherche Agronomique
ClinicalTrials.gov Identifier: NCT00931151     History of Changes
Other Study ID Numbers: SURPROL 2
First Submitted: July 1, 2009
First Posted: July 2, 2009
Last Update Posted: August 23, 2011
Last Verified: March 2010

Additional relevant MeSH terms:
Overweight
Body Weight
Signs and Symptoms