Genetic and Environmental Risk Factors for Hemorrhagic Stroke-GERFHS III (GERFHS-III)
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ClinicalTrials.gov Identifier: NCT00930280 |
Recruitment Status :
Active, not recruiting
First Posted : June 30, 2009
Last Update Posted : July 2, 2021
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Condition or disease |
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Stroke |
Study Type : | Observational |
Estimated Enrollment : | 1260 participants |
Observational Model: | Case-Control |
Time Perspective: | Prospective |
Official Title: | Genetic and Environmental Risk Factors for Hemorrhagic Stroke |
Study Start Date : | July 2008 |
Estimated Primary Completion Date : | June 2022 |
Estimated Study Completion Date : | June 2022 |

Group/Cohort |
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Hemorrhagic stroke cases
People who have had a hemorrhagic stroke, specifically an intracerebral hemorrhage, and live within a 100 mile radius of the University of Cincinnati.
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Healthy Control Subjects
Healthy volunteers who are randomly identified in the same 100 mile radius of the University of Cincinnati and have not had a hemorrhagic stroke.
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- The analysis of the presence of specific genetic markers associated with hemorrhagic stroke versus the control group. [ Time Frame: Ongoing to be completed at the end of June 2013. ]Identification of specific genetic markers for each subject will be measured by gene assay using the Affymetrix chip. We are looking for SNPs that persist after controlling for traditional risk factors such as hypertension, smoking exposure, diabetes, alcohol use, anticoagulant use, hypercholesterolemia and APOE alleles.
- Analysis of risk factors such as age, race, gender, current smoking, heavy alcohol use, use of anticoagulants, diabetes, hemorrhagic stroke family history, hypertension, etc. in people with hemorrhagic stroke versus the control group. [ Time Frame: Ongoing to be completed at the end of June 2013. ]Traditional risk factors will be identified through self report during interview and by hospital chart notes for the case subjects. Identification of the APOE alleles for each subject will be done on their genetic sample.
Biospecimen Retention: Samples With DNA

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Ages Eligible for Study: | 18 Years and older (Adult, Older Adult) |
Sexes Eligible for Study: | All |
Accepts Healthy Volunteers: | Yes |
Sampling Method: | Non-Probability Sample |
Inclusion Criteria:
- Age 18 years or older
- Resident (6 months or longer) within 100 miles of University of Cincinnati.
- Fulfillment of the criteria for spontaneous ICH
- No evidence of trauma, brain tumor/metastases, hemorrhagic transformation of ischemic stroke or infectious processes as a cause of the hemorrhage.
- Ability of the patient or legal representative to provide consent for an interview, blood pressure determinations and DNA sampling.
Exclusion Criteria:
- N/A

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00930280
United States, Ohio | |
University of Cincinnati Department of Neurology | |
Cincinnati, Ohio, United States, 45267-0525 |
Principal Investigator: | Daniel Woo, M.D. | University of Cincinnati Department of Neurology |
Publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number):
Responsible Party: | Daniel Woo, Principal Investigator, University of Cincinnati |
ClinicalTrials.gov Identifier: | NCT00930280 |
Other Study ID Numbers: |
36695-3 5U01NS036695-16 ( U.S. NIH Grant/Contract ) |
First Posted: | June 30, 2009 Key Record Dates |
Last Update Posted: | July 2, 2021 |
Last Verified: | July 2021 |
Individual Participant Data (IPD) Sharing Statement: | |
Plan to Share IPD: | No |
stroke brain attack hemorrhagic stroke risk factors |
Stroke Hemorrhagic Stroke Cerebrovascular Disorders Brain Diseases |
Central Nervous System Diseases Nervous System Diseases Vascular Diseases Cardiovascular Diseases |