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Urokinase Like Plasminogen Activator Levels in Patients Undergoing Bronchoscopy

This study has been completed.
Sponsor:
ClinicalTrials.gov Identifier:
NCT00929565
First Posted: June 29, 2009
Last Update Posted: April 9, 2012
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
Information provided by (Responsible Party):
Gary Kinasewitz, University of Oklahoma
  Purpose

Some of the risk factors for bleeding following bronchoscopy is having a malignancy or an immunocompromised state. The etiology of this remains uncertain. The investigators suspect that individuals with malignancy have abnormalities involving certain factors that influence the coagulation pathway.

The investigators plan to measure these factors prior to and after bronchoscopy.


Condition
Hemoptysis

Study Type: Observational
Study Design: Observational Model: Case Control
Time Perspective: Prospective
Official Title: Utility of Serum and Bronchoalveolar Fluid Urokinase Like Plasminogen Activator Levels in Defining Patients at Higher Risk of Hemoptysis.

Further study details as provided by Gary Kinasewitz, University of Oklahoma:

Secondary Outcome Measures:
  • Volume of blood loss during the procedure [ Time Frame: 1 day ]

Enrollment: 10
Study Start Date: June 2009
Study Completion Date: October 2011
Primary Completion Date: June 2010 (Final data collection date for primary outcome measure)
Groups/Cohorts
Lung cancer
Comparison between individuals with and without pulmonary malignancy

Detailed Description:
This is a prospective observational study looking at some coagulation factors in individuals with lung cancer. We are looking at BAL and plasma. We would like to see if there is a difference in the levels and if this is the reason behind the higher incidence of hemoptysis in patients with lung cancer.
  Eligibility

Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years to 80 Years   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Probability Sample
Study Population
Patients from the VAMC in Oklahoma city
Criteria

Inclusion Criteria:

  • Any patient scheduled to undergo bronchoscopy

Exclusion Criteria:

  • Patients with evidence of coagulopathy either iatrogenic or the result of disease process - coagulopathy defined as elevated prothrombin time, activated partial thromboplastin time or platelet count less than 100,000
  • Patients not scheduled to undergo bronchoalveolar lavage (BAL)
  Contacts and Locations
Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00929565


Locations
United States, Oklahoma
VA Medical Center
Oklahoma City, Oklahoma, United States, 73104
Sponsors and Collaborators
University of Oklahoma
Investigators
Principal Investigator: Jijo John, MD University of Oklahoma
  More Information

Responsible Party: Gary Kinasewitz, Principal Investigator, University of Oklahoma
ClinicalTrials.gov Identifier: NCT00929565     History of Changes
Other Study ID Numbers: 14455
First Submitted: June 24, 2009
First Posted: June 29, 2009
Last Update Posted: April 9, 2012
Last Verified: April 2012

Keywords provided by Gary Kinasewitz, University of Oklahoma:
hemoptysis

Additional relevant MeSH terms:
Hemoptysis
Lung Diseases
Respiratory Tract Diseases
Hemorrhage
Pathologic Processes
Signs and Symptoms, Respiratory
Signs and Symptoms
Plasminogen
Fibrinolytic Agents
Fibrin Modulating Agents
Molecular Mechanisms of Pharmacological Action