Comparison of Cardiac Computed Tomography and Vasodilator Stress Magnetic Resonance Imaging Perfusion in Patients With Prior Equivocal Stress Test for Detection of Coronary Artery Disease
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|ClinicalTrials.gov Identifier: NCT00929227|
Recruitment Status : Completed
First Posted : June 26, 2009
Last Update Posted : February 7, 2018
- Noninvasive cardiac stress testing is imperfect. Inconclusive test results generate further expensive testing.
- In patients with known or suspected coronary artery disease, both computed tomography (CT) and magnetic resonance imaging (MRI) have been shown to provide suitable results for detecting the disease. However, both types of scans have limitations in their usefulness, and it is not known whether one is preferable in either accuracy or cost-effectiveness.
- To determine the accuracy and cost-effectiveness of CT and MRI in subjects with a prior inconclusive heart stress test.
- Patients 18 years of age and older who have had an inconclusive heart stress test within the past 90 days.
- A blood test will be obtained prior to both heart tests. This will require less than a teaspoon of blood.
- A CT scan will be performed, accompanied by beta blocker medications (to slow heart rate) or nitroglycerin (to enlarge blood vessels) to improve picture quality, as needed.
- An MRI scan will be performed. Scans will be taken before, during, and after the patient receives vasodilators (to increase blood flow to the coronary arteries and detect blockages in heart blood vessels).
- Heart rate and function will be monitored with an electrocardiogram.
|Condition or disease|
|Myocardial Ischemia Coronary Artery Disease Myocardial Infarction|
|Study Type :||Observational|
|Actual Enrollment :||109 participants|
|Official Title:||Comparison of Cardiac Computed Tomography and Vasodilator Stress Magnetic Resonance Imaging Perfusion in Patients With Prior Equivocal Stress Test for Detection of Coronary Artery Disease|
|Study Start Date :||June 24, 2009|
- Stress MRI perfusion is more cost-effective than cardiac CT in patients with an equivocal stress study in predicting CAD, or vise versa.
- Stress MRI perfusion and/or cardiac CTA will maintain reasonable sensitivity, specificity, and accuracy in predicting CAD in a patient population with prior equivocal stress testing.
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00929227
|United States, Maryland|
|Bethesda, Maryland, United States, 20814|
|National Institutes of Health Clinical Center, 9000 Rockville Pike|
|Bethesda, Maryland, United States, 20892|
|Principal Investigator:||Andrew E Arai, M.D.||National Heart, Lung, and Blood Institute (NHLBI)|