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Mechanisms of Neural Mobilization in the Treatment of Chronic Pain

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ClinicalTrials.gov Identifier: NCT00929123
Recruitment Status : Completed
First Posted : June 26, 2009
Last Update Posted : March 17, 2015
Sponsor:
Collaborator:
Information provided by (Responsible Party):

Study Description
Brief Summary:
The purpose of this study was to determine the effect of a manual therapy technique (neural mobilization) on measures of clinical pain and function, experimental pain sensitivity, and on the function of the median nerve in individuals with carpal tunnel syndrome. The investigators hypothesized that individuals receiving a neural mobilization technique known to directly stress the median nerve would demonstrate greater improvements in clinical pain and function, experimental pain sensitivity, and median nerve function than those receiving a sham technique.

Condition or disease Intervention/treatment Phase
Carpal Tunnel Syndrome Procedure: neural mobilization Procedure: sham neural mobilization Other: healthy controls Phase 1 Phase 2

Study Design

Study Type : Interventional  (Clinical Trial)
Actual Enrollment : 40 participants
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)
Primary Purpose: Treatment
Official Title: Mechanisms of Neural Mobilization in the Treatment of Chronic Pain
Study Start Date : May 2007
Primary Completion Date : July 2008
Study Completion Date : June 2009


Arms and Interventions

Arm Intervention/treatment
Experimental: neural mobilization
manual therapy technique known to directly stress the median nerve
Procedure: neural mobilization
manual therapy technique known to directly stress the median nerve
Other Name: upper limb tension test with median nerve bias
Placebo Comparator: sham neural mobilization
manual therapy technique known to directly stress the median nerve without any stimulation.
Procedure: sham neural mobilization
sham technique mimicking the neural mobilization which is not specific to the median nerve
Active Comparator: Healthy Controls
People without carpal tunnel syndrome for comparison
Other: healthy controls
People without carpal tunnel syndrome for comparison


Outcome Measures

Primary Outcome Measures :
  1. thermal and pressure pain sensitivity [ Time Frame: immediate effect ]

Secondary Outcome Measures :
  1. grip strength [ Time Frame: 3 weeks ]
  2. wrist range of motion [ Time Frame: 3 weeks ]
  3. clinical pain [ Time Frame: 3 weeks ]
  4. self report of disability [ Time Frame: 3 weeks ]
  5. median nerve function [ Time Frame: 3 weeks ]

Eligibility Criteria

Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years to 70 Years   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Criteria

Inclusion Criteria:

  • 18 to 70 years of age
  • signs and symptoms of carpal tunnel syndrome for greater than 12 weeks

Exclusion Criteria:

  • non english speaking
  • prior surgery for carpal tunnel syndrome
  • systemic condition known to affect sensation
  • chronic pain condition other than carpal tunnel syndrome
Contacts and Locations

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00929123


Locations
United States, Florida
University of Florida
Gainesville, Florida, United States, 32611
Sponsors and Collaborators
University of Florida
National Center for Complementary and Integrative Health (NCCIH)
Investigators
Principal Investigator: Steven Z George, PhD University of Florida Department of Physical Therapy
More Information

Publications:
Responsible Party: University of Florida
ClinicalTrials.gov Identifier: NCT00929123     History of Changes
Other Study ID Numbers: R21AT002796 ( U.S. NIH Grant/Contract )
R21AT002796-01A1 ( U.S. NIH Grant/Contract )
First Posted: June 26, 2009    Key Record Dates
Last Update Posted: March 17, 2015
Last Verified: March 2015

Keywords provided by University of Florida:
manual therapy
carpal tunnel syndrome
central sensitization

Additional relevant MeSH terms:
Chronic Pain
Carpal Tunnel Syndrome
Pain
Neurologic Manifestations
Nervous System Diseases
Signs and Symptoms
Median Neuropathy
Mononeuropathies
Peripheral Nervous System Diseases
Neuromuscular Diseases
Nerve Compression Syndromes
Cumulative Trauma Disorders
Sprains and Strains
Wounds and Injuries