Oxidative Stress Markers in Open and Laparoscopic Colectomy for Cancer

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT00928928
Recruitment Status : Completed
First Posted : June 26, 2009
Last Update Posted : June 26, 2009
University of Ioannina
Information provided by:
G. Hatzikosta General Hospital

Brief Summary:
Contribution to the study of oxidative stress markers in laparoscopic vs open colectomy for colorectal cancer

Condition or disease Intervention/treatment Phase
Colorectal Cancer Procedure: Open colectomy Procedure: laparoscopic colectomy Phase 4

Study Type : Interventional  (Clinical Trial)
Actual Enrollment : 40 participants
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Double (Participant, Outcomes Assessor)
Official Title: Study of the Oxidative Stress in Patients With Colorectal Cancer. Open vs Laparoscopic Approach
Study Start Date : January 2008
Actual Primary Completion Date : June 2009

Resource links provided by the National Library of Medicine

U.S. FDA Resources

Arm Intervention/treatment
Active Comparator: Open group
Group of patients operated with open approach for colorectal cancer
Procedure: Open colectomy
Open colectomy. Epidural anaesthesia used
Active Comparator: laparoscopic group
Group of patients operated with laparoscopic approach for colorectal cancer
Procedure: laparoscopic colectomy
Laparoscopic colectomy. Epidural anaesthesia used

Primary Outcome Measures :
  1. Oxidative stress markers in patients with colorectal cancer operated with open or laparoscopic approach [ Time Frame: preoperative, intraoperative, 6h postop, 24h postop ]

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Ages Eligible for Study:   Child, Adult, Senior
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No

Inclusion Criteria:

  • colorectal cancer

Exclusion Criteria:

  • metastases
  • recurrent disease
  • chronic diseases

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT00928928

G Hatzikosta General Hospital
Ioannina, Greece, 45001
Sponsors and Collaborators
G. Hatzikosta General Hospital
University of Ioannina

Publications automatically indexed to this study by Identifier (NCT Number):
Responsible Party: George Pappas-Gogos,MD, G Hatzikosta General Hospital, Ioannina, Greece Identifier: NCT00928928     History of Changes
Other Study ID Numbers: GH-1948-03
First Posted: June 26, 2009    Key Record Dates
Last Update Posted: June 26, 2009
Last Verified: June 2009

Keywords provided by G. Hatzikosta General Hospital:
Lipid peroxidation
Protein peroxidation
DNA peroxidation
RNA peroxidation
Oxidative stress markers
Open surgery
Laparoscopic surgery

Additional relevant MeSH terms:
Colorectal Neoplasms
Intestinal Neoplasms
Gastrointestinal Neoplasms
Digestive System Neoplasms
Neoplasms by Site
Digestive System Diseases
Gastrointestinal Diseases
Colonic Diseases
Intestinal Diseases
Rectal Diseases