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The Effect of Liquorice on Plasma Potassium

This study has been terminated.
(When 9 subjects of targeted 12 subjects had been studied, no changes in plasma potassium were detected and it was deemed futile to continue with enrolment.)
Information provided by:
University of Oulu Identifier:
First received: June 22, 2009
Last updated: April 6, 2010
Last verified: April 2010
The hypothesis is that liquorice lowers plasma potassium. This study aims to elucidate the dose-response of this effect with two doses of liquorice (66 grams or 102 grams) per day for two weeks.

Condition Intervention
Other: Liquorice 66 g/day
Other: Liquorice 102 g/day

Study Type: Interventional
Study Design: Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Open Label
Official Title: Lakritsin Vaikutus Kaliumpitoisuuteen

Resource links provided by NLM:

Further study details as provided by University of Oulu:

Primary Outcome Measures:
  • Change in plasma potassium [ Time Frame: 1 week, 2 weeks ]

Enrollment: 9
Study Start Date: June 2009
Study Completion Date: March 2010
Primary Completion Date: March 2010 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Active Comparator: Liquorice 66 g/day
Liquorice given 66 grams per day for two weeks
Other: Liquorice 66 g/day
Liquorice 66 g/day for two weeks
Other Name: Pepe Original liquorice
Active Comparator: Liquorice 102 g/day
Liquorice given 102 grams per day for two weeks
Other: Liquorice 102 g/day
Liquorice 102 g/day for two weeks
Other Name: Pepe Original liquorice


Ages Eligible for Study:   18 Years to 40 Years   (Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes

Inclusion Criteria:

  • healthy volunteers
  • age 18-40

Exclusion Criteria:

  • any continuous medication
  • hypertension or hypotension
  • allergy to liquorice
  • pregnancy or lactation
  • difficult venipuncture
  • drug or alcohol abuse
  • participation in pharmaceutical trial
  Contacts and Locations
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Please refer to this study by its identifier: NCT00927017

Oulu University Hospital
Oulu, Finland, 90220
Sponsors and Collaborators
University of Oulu
Principal Investigator: Janne Hukkanen, MD, PhD Oulu University Hospital, Department of Internal Medicine
  More Information

Responsible Party: Janne Hukkanen, Oulu University Hospital, Department of Internal Medicine Identifier: NCT00927017     History of Changes
Other Study ID Numbers: Lakritsi-2
Study First Received: June 22, 2009
Last Updated: April 6, 2010

Keywords provided by University of Oulu:
Healthy volunteers processed this record on April 26, 2017