The Role of the Glutamatergic System in the Extinction of Conditioned Reinforcement Processes (SFB636D6)
Recruitment status was: Recruiting
The aim of this project is to explore whether the extinction of cue-reactivity following a cue-exposure based intervention in volunteers with an alcohol dependence is facilitated by drugs that increase NMDA-receptor function.
It is hypothesised that targeted treatment with D-Cycloserine prior to each extinction training session enhances the effects on cue-reactivity.
Further, a significant correlation between the reduction of cue-reactivity and both reduced craving and relapse probability is expected.
|Study Design:||Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Double Blind (Subject, Caregiver, Investigator, Outcomes Assessor)
Primary Purpose: Basic Science
|Official Title:||The Role of the Glutamatergic System in the Extinction of Conditioned Reinforcement Processes|
- reduction in cue-reactivity to alcohol-associated stimuli assessed by functional magnetic resonance imaging [ Time Frame: following completion of cue-exposure therapy ] [ Designated as safety issue: No ]
- time to first severe relapse to alcohol consumption [ Time Frame: at 3 and 6 months after treatment completion ] [ Designated as safety issue: No ]
|Study Start Date:||March 2009|
|Estimated Primary Completion Date:||April 2012 (Final data collection date for primary outcome measure)|
|Active Comparator: D-cycloserine||
50 mg at approximately 1.5 hours prior to cue-exposure training sessions
|Placebo Comparator: Placebo||
Please refer to this study by its ClinicalTrials.gov identifier: NCT00926900
|Central Institute of Mental Health|
|Mannheim, Germany, 68159|
|Principal Investigator:||Falk Kiefer, Professor||Central Institute of Mental Health, Department of Addictive Behavior and Addiction Medicine|