The Role of the Glutamatergic System in the Extinction of Conditioned Reinforcement Processes (SFB636D6)
Recruitment status was Recruiting
The aim of this project is to explore whether the extinction of cue-reactivity following a cue-exposure based intervention in volunteers with an alcohol dependence is facilitated by drugs that increase NMDA-receptor function.
It is hypothesised that targeted treatment with D-Cycloserine prior to each extinction training session enhances the effects on cue-reactivity.
Further, a significant correlation between the reduction of cue-reactivity and both reduced craving and relapse probability is expected.
|Study Design:||Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Double Blind (Subject, Caregiver, Investigator, Outcomes Assessor)
Primary Purpose: Basic Science
|Official Title:||The Role of the Glutamatergic System in the Extinction of Conditioned Reinforcement Processes|
- reduction in cue-reactivity to alcohol-associated stimuli assessed by functional magnetic resonance imaging [ Time Frame: following completion of cue-exposure therapy ] [ Designated as safety issue: No ]
- time to first severe relapse to alcohol consumption [ Time Frame: at 3 and 6 months after treatment completion ] [ Designated as safety issue: No ]
|Study Start Date:||March 2009|
|Estimated Primary Completion Date:||April 2012 (Final data collection date for primary outcome measure)|
|Active Comparator: D-cycloserine||
50 mg at approximately 1.5 hours prior to cue-exposure training sessions
|Placebo Comparator: Placebo||
Please refer to this study by its ClinicalTrials.gov identifier: NCT00926900
|Contact: Falk Kiefer, Professor||+49 621 1703 firstname.lastname@example.org|
|Central Institute of Mental Health||Recruiting|
|Mannheim, Germany, 68159|
|Contact: Falk Kiefer, Professor +49 621 1703 3522 email@example.com|
|Principal Investigator: Falk Kiefer, Professor|
|Principal Investigator:||Falk Kiefer, Professor||Central Institute of Mental Health, Department of Addictive Behavior and Addiction Medicine|