Assessing Anterior Cingulate Brain Activity in People With Late-Life Depression
This study will examine differences in activity of the anterior cingulate cortex, a brain area involved in emotion and cognitive regulation, between older adults with and without depression.
|Study Design:||Observational Model: Cohort
Time Perspective: Prospective
|Official Title:||Anterior Cingulate Activation in Geriatric Depression|
- Cerebral activation, as measured using functional magnetic resonance imaging (fMRI) [ Time Frame: Average of a 2 hour MRI session ] [ Designated as safety issue: No ]
|Study Start Date:||July 2005|
|Study Completion Date:||May 2010|
|Primary Completion Date:||May 2010 (Final data collection date for primary outcome measure)|
Elderly participants with depression
10 to 20 mg daily as part of another study in which participants are enrolled
Other Name: Lexapro
Elderly participants who have never experienced depression
Older adults with depression often also suffer from executive dysfunction—problems with planning, impulse control, and reasoning. Executive dysfunction in older adults predicts poor or delayed response to antidepressant treatment and has been associated with early relapse and recurrence of late-life major depression. Functional magnetic resonance imaging (fMRI) is a scan that can measure the activity of someone's brain while that person performs tasks. So far, no fMRI studies investigating cerebral activation patterns in late-life depression have been published. In this study, people will undergo fMRI while they are performing an executive function task. Older adults with late-life depression and older adults without depression will be tested and compared in order to identify the areas and patterns of brain activity underlying executive dysfunction in late-life depression.
Participation in this study will consist of one study visit, during which participants will undergo an fMRI scan that will last 60 to 90 minutes. While being scanned, participants will perform cognitive tasks that involve pressing buttons in response to words viewed on a screen.
Please refer to this study by its ClinicalTrials.gov identifier: NCT00926653
|United States, New York|
|New York Presbyterian-Weill Cornell Medical College|
|White Plains, New York, United States, 10605|
|Principal Investigator:||Faith M. Gunning-Dixon, PhD||Weill Medical College of Cornell University|