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Study Comparing Cortical Function and Dysfunction Tests in Low Back Pain

This study has been completed.
Information provided by (Responsible Party):
olavi airaksinen, Kuopio University Hospital Identifier:
First received: June 18, 2009
Last updated: February 10, 2013
Last verified: September 2012
The purpose of this study is to explore the cortical regulation of the paraspinal muscles in chronic low back pain. These (possible) changes in regulatory mechanisms are being compared to other motor control tests in order to determine whether correlations are found. Furthermore the patients are being treated with repetitive transcranial magnetic stimulation (rTMS) and tested afterwards. The purpose is to find out if rTMS-therapy is capable of normalizing motor control deficits.

Condition Intervention
Chronic Nonspecific Low Back Pain
Device: transcranial magnetic stimulation

Study Type: Interventional
Study Design: Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single Blind (Participant)
Primary Purpose: Basic Science
Official Title: Regulatory Central Mechanisms in Chronic Nonspecific Low Back Pain With Lumbar Dysfunction

Resource links provided by NLM:

Further study details as provided by Kuopio University Hospital:

Primary Outcome Measures:
  • Correlation between cortical activity and other motor control tests [ Time Frame: day 1 and day 19 ]

Secondary Outcome Measures:
  • The effect of rTMS-therapy for clinical outcome and motor control tests [ Time Frame: day 19, 1 month, 2 months, 1 year ]

Enrollment: 80
Study Start Date: June 2009
Study Completion Date: September 2012
Primary Completion Date: September 2012 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Active Comparator: Cortical function
Activity/inhibition of the cortex
Device: transcranial magnetic stimulation
rTMS therapy daily for two weeks, five times per week each lasting for half an hour
Active Comparator: Cortical regulation Device: transcranial magnetic stimulation
rTMS therapy daily for two weeks, five times per week each lasting for half an hour


Ages Eligible for Study:   25 Years to 50 Years   (Adult)
Sexes Eligible for Study:   Male
Accepts Healthy Volunteers:   Yes

Inclusion Criteria:

  • chronic nonspecific low back pain for at least six months
  • male gender
  • age 25-50 yrs
  • average pain during last week 4-8/10 by VAS
  • Oswestry disability index 20-80 %

Exclusion Criteria:

  • former spinal operations
  • rheumatic disease, marked spondylolysis and -olisthesis, other diseases that markedly reduce physical or psychological performance, history of epilepsy, history of taking epileptic or strong opioid drugs
  Contacts and Locations
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Please refer to this study by its identifier: NCT00924495

Kuopio University Hospital
Kuopio, Finland, 70211
Sponsors and Collaborators
Kuopio University Hospital
Principal Investigator: Marja T Kilpiäinen, MD Kuopio University Hospital
Study Director: Markku Kankaanpää, MD,PhD Tampere University Hospital
Study Chair: Olavi Airaksinen, MD, PhD Kuopio University Hospital
Study Chair: Timo Miettinen, MD,PhD Kuopio University Hospital
Study Chair: Eeva Leino, MD,PhD Tampere University Hospital
  More Information

Responsible Party: olavi airaksinen, MD, PhD Ass Proff, Head of the Department of Rehabilitation, Kuopio University Hospital Identifier: NCT00924495     History of Changes
Other Study ID Numbers: KUH5960429
Study First Received: June 18, 2009
Last Updated: February 10, 2013

Keywords provided by Kuopio University Hospital:
low back pain
motor control
cortical regulation
transcranial magnetic stimulation

Additional relevant MeSH terms:
Back Pain
Low Back Pain
Neurologic Manifestations
Nervous System Diseases
Signs and Symptoms processed this record on May 22, 2017