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Effect of Passive Smoking on Platelet Function and Endothelial Function

This study has been completed.
Sponsor:
ClinicalTrials.gov Identifier:
NCT00923988
First Posted: June 18, 2009
Last Update Posted: August 11, 2009
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
Information provided by:
Kantonsspital Graubünden
  Purpose
Passive smoking is associated with an increased risk for cardiovascular events. However, the exact mechanisms by which passive smoking affects cardiovascular health are not entirely understood. In the present study, the researchers investigate the effects of short-term exposure to secondhand smoke on platelet function and peripheral microvascular endothelial function in healthy individuals. For this purpose, platelet function and endothelial function are measured before and after a 1-hour exposure to secondhand smoke in a concentration that is encountered in bars and restaurants without smoke-free policies. The researchers' hypothesis is that short-term exposure leads to platelet activation and impairment of endothelial function.

Condition Intervention
Endothelial Function Platelet Aggregation Other: secondhand smoke exposure

Study Type: Interventional
Study Design: Intervention Model: Single Group Assignment
Masking: None (Open Label)
Primary Purpose: Prevention
Official Title: Acute Effects of Short-term Exposure to Secondhand Smoke on Platelet Activation and Endothelial Function

Resource links provided by NLM:


Further study details as provided by Kantonsspital Graubünden:

Primary Outcome Measures:
  • Change in platelet aggregation and/or endothelial function [ Time Frame: 12-24 hours ]

Estimated Enrollment: 40
Study Start Date: June 2009
Study Completion Date: August 2009
Primary Completion Date: August 2009 (Final data collection date for primary outcome measure)
Intervention Details:
    Other: secondhand smoke exposure
    Participants will be exposed to secondhand smoke for one hour. As a measure of secondhand smoke exposition, room carbon monoxide concentration will be continuously measured using an Ambient Carbon Monoxide Monitor APMA-360 and kept constant between 4.5-6.0 ppm. Levels in this magnitude are typically seen in smoking areas of restaurants and bars.
  Eligibility

Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years to 50 Years   (Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Criteria

Inclusion Criteria:

  • healthy individuals
  • nonsmokers
  • no regular medication (in particular no drugs affecting platelet function or vascular function)

Exclusion Criteria:

  • exposition to secondhand smoke within 1 week before inclusion
  • use of drugs affecting platelet function or vascular function within 1 week before study inclusion
  Contacts and Locations
Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00923988


Locations
Switzerland
Kantonsspital Graubuenden
Chur, Switzerland, 7000
Sponsors and Collaborators
Kantonsspital Graubünden
Investigators
Principal Investigator: Piero O. Bonetti, MD Division of Cardiology, Department of Internal Medicine, Kantonsspital Graubuenden, Loestrasse 170, CH-7000 Chur, Switzerland
  More Information

Responsible Party: Walter H. Reinhart, Head of the Department of Internal Medicine, Kantonsspital Graubuenden, Kantonsspital Graubuenden, Chur, Switzerland
ClinicalTrials.gov Identifier: NCT00923988     History of Changes
Other Study ID Numbers: SHS-EF
First Submitted: June 17, 2009
First Posted: June 18, 2009
Last Update Posted: August 11, 2009
Last Verified: August 2009

Keywords provided by Kantonsspital Graubünden:
Secondhand smoke
passive smoking
platelet function
endothelial function