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Methadone in Pediatric Anesthesia

This study has been completed.
Information provided by (Responsible Party):
Washington University School of Medicine Identifier:
First received: June 10, 2009
Last updated: May 8, 2017
Last verified: May 2017
This study will determine the pharmacokinetics of intravenous (IV) methadone in children undergoing surgery.

Condition Intervention
Drug: Methadone

Study Type: Interventional
Study Design: Intervention Model: Single Group Assignment
Masking: No masking
Primary Purpose: Treatment
Official Title: Methadone in Pediatric Anesthesia

Resource links provided by NLM:

Further study details as provided by Washington University School of Medicine:

Primary Outcome Measures:
  • Determine PKs of IV methadone in children undergoing surgery [ Time Frame: 1 year ]

Enrollment: 31
Actual Study Start Date: May 2009
Study Completion Date: May 2017
Primary Completion Date: May 2017 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Experimental: Methadone
Methadone administration 0.1mg/kg, 0.2mg/kg or 0.3 mg/kg
Drug: Methadone
Subjects will receive methadone as their intraoperative opioid.


Ages Eligible for Study:   5 Years to 18 Years   (Child, Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No

Inclusion Criteria:

  • Age 5-18
  • Undergoing General anesthesia and surgery with anticipated postoperative inpatient stay of greater than or equal to 3 days
  • Signed, written, informed consent from legal guardians and assent from patient

Exclusion Criteria:

  • History of or known liver or kidney disease
  Contacts and Locations
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Please refer to this study by its identifier: NCT00921843

United States, Missouri
Washington University School of Medicine
Saint Louis, Missouri, United States, 63110
Sponsors and Collaborators
Washington University School of Medicine
Principal Investigator: Evan Kharasch, MD, PhD Washington University School of Medicine
  More Information

Responsible Party: Washington University School of Medicine Identifier: NCT00921843     History of Changes
Other Study ID Numbers: 08-1195
Study First Received: June 10, 2009
Last Updated: May 8, 2017

Keywords provided by Washington University School of Medicine:
Pediatric patients undergoing surgery

Additional relevant MeSH terms:
Analgesics, Opioid
Central Nervous System Depressants
Physiological Effects of Drugs
Sensory System Agents
Peripheral Nervous System Agents
Antitussive Agents
Respiratory System Agents processed this record on May 24, 2017