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Computed Tomography Coronary Angiography (CTCA) and Coronary Flow in Stenosis Analysis

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ClinicalTrials.gov Identifier: NCT00921440
Recruitment Status : Completed
First Posted : June 16, 2009
Last Update Posted : June 16, 2009
Sponsor:
Collaborator:
Dept. of Radiology
Information provided by:
University of Cologne

Brief Summary:
The investigators' rationale was to evaluate whether a 64-slice CT scanner allows accurate measurement of computed tomographic changes in coronary artery flow profiles and whether CT flow measurements are suitable for classifying the significance and hemodynamic relevance of a stenosis and thereby supplement as a functional parameter for morphological stenosis analysis.

Condition or disease
Coronary Artery Disease

Detailed Description:
A total of 50 patients prospectively underwent computed tomography coronary angiography (CTCA) in a multidetector CT scanner (Brilliance 64, Philips) ± 1 day before or after invasive coronary angiography (ICA). Immediately thereafter, 2 radiologists reviewed the imaging data to detect any vessel segments with morphology poorly evaluable by CTCA. A locally constant cyclical measurement was acquired in these coronary arteries in breath-hold technique during the passage of a 50ml bolus of contrast media. For analysis, time-density curves of the bolus passage were registered in the coronary artery and the aorta (internal reference), the up-slopes were determined and correlated with each other. The results were compared with the ICA findings.

Study Type : Observational
Actual Enrollment : 50 participants
Observational Model: Cohort
Time Perspective: Prospective
Official Title: CT Coronary Angiography: Coronary Flow Quantification Supplements Morphological Stenosis Analysis
Study Start Date : August 2007
Actual Primary Completion Date : July 2008
Actual Study Completion Date : July 2008




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Ages Eligible for Study:   51 Years and older   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Probability Sample
Study Population
people with suspected or known coronary artery disease (CAD)
Criteria

Inclusion Criteria:

  • Clinically known or presumed CAD
  • Age > 50 years
  • Hospitalization for invasive coronary angiography
  • Sinus rhythm
  • Written informed consent by the patient to participate in the study after comprehensive presentation of the facts

Exclusion Criteria:

  • Age <= 50 years
  • Contraindications to contrast media administration (medical history of iodine allergy, nephropathy, latent or manifest hyperthyroidism)
  • Arrhythmias
  • Dyspnea at rest, acute unstable angina pectoris, acute myocardial infarction
  • Pregnancy
  • Implanted pacemaker
  • Unwillingness of patient to consent to the study

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00921440


Sponsors and Collaborators
University of Cologne
Dept. of Radiology
Investigators
Principal Investigator: Barbara Krug, Prof. Dr. Dept. of Radiology, University Hospital of Cologne

Responsible Party: Prof. Dr. med. Barbara Krug, University Hospital of Cologne, Dept. Radiology
ClinicalTrials.gov Identifier: NCT00921440     History of Changes
Other Study ID Numbers: 22462/2 - 2005-070
First Posted: June 16, 2009    Key Record Dates
Last Update Posted: June 16, 2009
Last Verified: June 2009

Keywords provided by University of Cologne:
coronary artery
stenosis

Additional relevant MeSH terms:
Coronary Artery Disease
Myocardial Ischemia
Coronary Disease
Constriction, Pathologic
Heart Diseases
Cardiovascular Diseases
Arteriosclerosis
Arterial Occlusive Diseases
Vascular Diseases
Pathological Conditions, Anatomical