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Biomarker-enhanced ED Disposition Decisions (BANC4)

This study has been completed.
Information provided by (Responsible Party):
University Hospital, Basel, Switzerland Identifier:
First received: June 12, 2009
Last updated: December 12, 2014
Last verified: December 2014

Patients presenting to emergency departments (ED) with non-specific complaints (NSC) such as "not feeling well", "feeling weak", "being tired", "general deterioration" are a very common and well-known, but poorly studied patient group. The differential diagnosis of NSC is extremely broad ranging from insufficient home care to acute life-threatening conditions. Therefore, the evaluation and diagnostic work-up of these mostly elderly patients with NSC is very time-consuming and not straight-forward. Furthermore, the assessment is complicated by comorbidities, polypharmacy or an altered mental status. For this reason, potentially unnecessary diagnostic efforts are undertaken in order to exclude a serious underlying condition, leading to prolonged throughput times and ED observation unit stays.

On the other hand, the patients` condition might be underestimated by ED physicians, which may result in ineffective, delayed or inadequate disposition, as well as poor patient outcomes. BANC (formerly BAUCAS) is a series of clinical studies with the intention to investigate the usefulness of clinical findings and biomarker levels combined for disposition of patients with non-specific complaints presenting to the emergency department.

Condition Intervention
Non-specific Complaints
Biological: biomarker-enhanced disposition decision with proADM

Study Type: Observational
Study Design: Observational Model: Cohort
Time Perspective: Cross-Sectional
Official Title: BANC4 (BASEL NON - SPECIFIC COMPLAINTS 4) Biomarker-enhanced Disposition Decisions

Further study details as provided by University Hospital, Basel, Switzerland:

Primary Outcome Measures:
  • serious condition (potentially life-threatening or requiring early intervention to prevent health status deterioration) [ Time Frame: 30 days ]

Secondary Outcome Measures:
  • 30 day mortality [ Time Frame: 30 days ]

Biospecimen Retention:   Samples Without DNA
whole blood (MR-proADM)

Enrollment: 400
Study Start Date: July 2011
Study Completion Date: July 2014
Primary Completion Date: July 2014 (Final data collection date for primary outcome measure)
Groups/Cohorts Assigned Interventions
patients with non-specific complaints
patients who do not have specific presenting symptoms (e.g. dyspnea, chest pain etc.)
Biological: biomarker-enhanced disposition decision with proADM
To compare the outcome of standard of care with an approach combining the standardized course and biomarker levels (biomarker-enhanced disposition decision with proADM) for the disposition of patients with non-specific complaints presenting to the emergency department (ED), in order to evaluate safety.


Ages Eligible for Study:   18 Years and older   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population
The protocol of the BANC study specifies that patients are consecutively enrolled in order to obtain a random sample of the source population of ED self-referred and referred patients with UC

Inclusion Criteria:

  • All adult non-trauma patients with an Emergency Severity Index (ESI) of 2 or 3 are screened for inclusion

Exclusion Criteria:

  • patients with specific chief complaints are excluded. Moreover, patients in whom an unambiguous and clear working hypothesis with logical management steps can be established are excluded
  Contacts and Locations
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Please refer to this study by its identifier: NCT00920491

University Hospital Basel
Basel, Switzerland, 4031
Sponsors and Collaborators
University Hospital, Basel, Switzerland
Principal Investigator: Roland Bingisser, MD University Hospital, Basel, Switzerland
  More Information

Publications automatically indexed to this study by Identifier (NCT Number):

Responsible Party: University Hospital, Basel, Switzerland Identifier: NCT00920491     History of Changes
Other Study ID Numbers: ED UHBS
Study First Received: June 12, 2009
Last Updated: December 12, 2014

Keywords provided by University Hospital, Basel, Switzerland:
Chief complaint
non-specific symptoms
general weakness / general deterioration
risk assessment in ED patients with non-specific symptoms processed this record on April 27, 2017