Biomarker-enhanced ED Disposition Decisions (BANC4)
Patients presenting to emergency departments (ED) with non-specific complaints (NSC) such as "not feeling well", "feeling weak", "being tired", "general deterioration" are a very common and well-known, but poorly studied patient group. The differential diagnosis of NSC is extremely broad ranging from insufficient home care to acute life-threatening conditions. Therefore, the evaluation and diagnostic work-up of these mostly elderly patients with NSC is very time-consuming and not straight-forward. Furthermore, the assessment is complicated by comorbidities, polypharmacy or an altered mental status. For this reason, potentially unnecessary diagnostic efforts are undertaken in order to exclude a serious underlying condition, leading to prolonged throughput times and ED observation unit stays.
On the other hand, the patients` condition might be underestimated by ED physicians, which may result in ineffective, delayed or inadequate disposition, as well as poor patient outcomes. BANC (formerly BAUCAS) is a series of clinical studies with the intention to investigate the usefulness of clinical findings and biomarker levels combined for disposition of patients with non-specific complaints presenting to the emergency department.
|Non-specific Complaints||Biological: biomarker-enhanced disposition decision with proADM|
|Study Design:||Observational Model: Cohort
Time Perspective: Cross-Sectional
|Official Title:||BANC4 (BASEL NON - SPECIFIC COMPLAINTS 4) Biomarker-enhanced Disposition Decisions|
- serious condition (potentially life-threatening or requiring early intervention to prevent health status deterioration) [ Time Frame: 30 days ]
- 30 day mortality [ Time Frame: 30 days ]
Biospecimen Retention: Samples Without DNA
|Study Start Date:||July 2011|
|Study Completion Date:||July 2014|
|Primary Completion Date:||July 2014 (Final data collection date for primary outcome measure)|
patients with non-specific complaints
patients who do not have specific presenting symptoms (e.g. dyspnea, chest pain etc.)
Biological: biomarker-enhanced disposition decision with proADM
To compare the outcome of standard of care with an approach combining the standardized course and biomarker levels (biomarker-enhanced disposition decision with proADM) for the disposition of patients with non-specific complaints presenting to the emergency department (ED), in order to evaluate safety.
Please refer to this study by its ClinicalTrials.gov identifier: NCT00920491
|University Hospital Basel|
|Basel, Switzerland, 4031|
|Principal Investigator:||Roland Bingisser, MD||University Hospital, Basel, Switzerland|