This site became the new on June 19th. Learn more.
Show more Menu IMPORTANT: Listing of a study on this site does not reflect endorsement by the National Institutes of Health. Talk with a trusted healthcare professional before volunteering for a study. Read more... Menu IMPORTANT: Talk with a trusted healthcare professional before volunteering for a study. Read more... Menu
Give us feedback

In-hospital Cardiac Arrest - Dynamics and State Transitions

This study has been completed.
Norwegian Air Ambulance Foundation
Norwegian University of Science and Technology
Information provided by (Responsible Party):
St. Olavs Hospital Identifier:
First received: June 12, 2009
Last updated: April 23, 2015
Last verified: April 2015
The purpose of this study is to analyse transitions in cardiac rhythm and hemodynamic variables during resuscitation of patients with in-hospital cardiac arrest.

Condition Intervention
Heart Arrest Death, Sudden, Cardiac Procedure: Cardiopulmonary resuscitation (CPR) Drug: Epinephrine Drug: Atropine Drug: Amiodarone Device: External defibrillator

Study Type: Observational
Study Design: Observational Model: Cohort
Time Perspective: Prospective
Official Title: Dynamics and State Transitions During Resuscitation in In-hospital Cardiac Arrest

Resource links provided by NLM:

Further study details as provided by St. Olavs Hospital:

Primary Outcome Measures:
  • Survival to discharge [ Time Frame: 1 year ]

Secondary Outcome Measures:
  • Short-term survival [ Time Frame: minutes-days ]

Enrollment: 285
Study Start Date: August 2009
Study Completion Date: April 2015
Primary Completion Date: April 2015 (Final data collection date for primary outcome measure)
Intervention Details:
    Procedure: Cardiopulmonary resuscitation (CPR)
    CPR is performed according to international and national guidelines on all patients.
    Other Name: CPR
    Drug: Epinephrine
    According to guidelines epinephrine 1 mg i.v. is administered every 3 minutes during cardiopulmonary resuscitation.
    Other Name: Adrenaline
    Drug: Atropine
    According to CPR guidelines atropine 3 mg i.v. is administered if asystole og PEA with frequency < 60 beat/min.
    Drug: Amiodarone
    According to guidelines amiodarone 300 mg i.v. is administered if recurrent ventricular fibrillation/tachycardia (VF/VT) during CPR.
    Other Name: Cordarone
    Device: External defibrillator
    According to CPR guidelines patients with shockable rhythms may receive DC shocks. The defibrillator also stores physiological information regarding cardiac rhythm, pulse-oximetry, and end-tidal carbon dioxide (CO2) from endotracheal tube.
    Other Name: Defibrillator
Detailed Description:
In-hospital cardiac arrest carries a grave prognosis, with survival to discharge in the range of 15-20%. Key factors determining outcome include the presenting cardiac rhythm, aetiology, and early initiation of resuscitation. Some cardiac rhythms benefit from defibrillation (shockable rhythms). During resuscitation patients may switch between shockable and non-shockable rhythms, and may show signs of spontaneous circulation temporarily. Depending on rhythm and according to guidelines, patients receive direct current (DC) shocks (defibrillator) and/or i.v. adrenaline, atropine and amiodarone, which may affect state-transitions. We wish to make statistical analysis (time-series analysis, Markov modelling) of these state-transitions and variations in hemodynamic variables during resuscitation, related to CPR interventions and the cause of arrest. The cause of arrest will be determined based on chart records, interview with staff and autopsy if appropriate. One hypothesis is that differences in the patterns of state-transitions may reflect underlying aetiology, which may guide in future decision-making during resuscitation.

Ages Eligible for Study:   18 Years and older   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population
Patients with in-hospital cardiac arrest at St.Olavs Hospital (Trondheim, Norway) during the study period.

Inclusion Criteria:

  • Patients with in-hospital cardiac arrest who are resuscitated

Exclusion Criteria:

  • Younger than 18 years old
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its identifier: NCT00920244

St.Olavs Hospital, Department of Anesthesia
Trondheim, Norway, 7014
Sponsors and Collaborators
St. Olavs Hospital
Norwegian Air Ambulance Foundation
Norwegian University of Science and Technology
Study Chair: Eirik Skogvoll, MD, PhD St. Olavs Hospital
Principal Investigator: Trond Nordseth, MD St. Olavs Hospital
  More Information

Publications automatically indexed to this study by Identifier (NCT Number):
Responsible Party: St. Olavs Hospital Identifier: NCT00920244     History of Changes
Other Study ID Numbers: 4.2008.2402 (REK)
08/11457 ( Other Identifier: SHDir )
20708/2/IB ( Other Identifier: NSD )
Study First Received: June 12, 2009
Last Updated: April 23, 2015

Keywords provided by St. Olavs Hospital:
Cardiac arrest

Additional relevant MeSH terms:
Heart Arrest
Death, Sudden
Death, Sudden, Cardiac
Heart Diseases
Cardiovascular Diseases
Pathologic Processes
Epinephryl borate
Adrenergic alpha-Agonists
Adrenergic Agonists
Adrenergic Agents
Neurotransmitter Agents
Molecular Mechanisms of Pharmacological Action
Physiological Effects of Drugs
Adrenergic beta-Agonists
Bronchodilator Agents
Autonomic Agents
Peripheral Nervous System Agents
Anti-Asthmatic Agents
Respiratory System Agents
Vasoconstrictor Agents
Adjuvants, Anesthesia
Anti-Arrhythmia Agents
Parasympatholytics processed this record on September 21, 2017