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In-hospital Cardiac Arrest - Dynamics and State Transitions

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT00920244
Recruitment Status : Completed
First Posted : June 15, 2009
Last Update Posted : September 5, 2018
Norwegian Air Ambulance Foundation
Norwegian University of Science and Technology
Information provided by (Responsible Party):
St. Olavs Hospital

Brief Summary:
The purpose of this study is to analyse transitions in cardiac rhythm and hemodynamic variables during resuscitation of patients with in-hospital cardiac arrest.

Condition or disease Intervention/treatment
Heart Arrest Death, Sudden, Cardiac Procedure: Cardiopulmonary resuscitation (CPR) Drug: Epinephrine Drug: Atropine Drug: Amiodarone Device: External defibrillator

Detailed Description:
In-hospital cardiac arrest carries a grave prognosis, with survival to discharge in the range of 15-20%. Key factors determining outcome include the presenting cardiac rhythm, aetiology, and early initiation of resuscitation. Some cardiac rhythms benefit from defibrillation (shockable rhythms). During resuscitation patients may switch between shockable and non-shockable rhythms, and may show signs of spontaneous circulation temporarily. Depending on rhythm and according to guidelines, patients receive direct current (DC) shocks (defibrillator) and/or i.v. adrenaline, atropine and amiodarone, which may affect state-transitions. We wish to make statistical analysis (time-series analysis, Markov modelling) of these state-transitions and variations in hemodynamic variables during resuscitation, related to CPR interventions and the cause of arrest. The cause of arrest will be determined based on chart records, interview with staff and autopsy if appropriate. One hypothesis is that differences in the patterns of state-transitions may reflect underlying aetiology, which may guide in future decision-making during resuscitation.

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Study Type : Observational
Actual Enrollment : 285 participants
Observational Model: Cohort
Time Perspective: Prospective
Official Title: Dynamics and State Transitions During Resuscitation in In-hospital Cardiac Arrest
Study Start Date : August 2009
Actual Primary Completion Date : April 2015
Actual Study Completion Date : April 2015

Resource links provided by the National Library of Medicine

Intervention Details:
  • Procedure: Cardiopulmonary resuscitation (CPR)
    CPR is performed according to international and national guidelines on all patients.
    Other Name: CPR
  • Drug: Epinephrine
    According to guidelines epinephrine 1 mg i.v. is administered every 3 minutes during cardiopulmonary resuscitation.
    Other Name: Adrenaline
  • Drug: Atropine
    According to CPR guidelines atropine 3 mg i.v. is administered if asystole og PEA with frequency < 60 beat/min.
  • Drug: Amiodarone
    According to guidelines amiodarone 300 mg i.v. is administered if recurrent ventricular fibrillation/tachycardia (VF/VT) during CPR.
    Other Name: Cordarone
  • Device: External defibrillator
    According to CPR guidelines patients with shockable rhythms may receive DC shocks. The defibrillator also stores physiological information regarding cardiac rhythm, pulse-oximetry, and end-tidal carbon dioxide (CO2) from endotracheal tube.
    Other Name: Defibrillator

Primary Outcome Measures :
  1. Survival to discharge [ Time Frame: 1 year ]

Secondary Outcome Measures :
  1. Short-term survival [ Time Frame: minutes-days ]

Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years and older   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population
Patients with in-hospital cardiac arrest at St.Olavs Hospital (Trondheim, Norway) during the study period.

Inclusion Criteria:

  • Patients with in-hospital cardiac arrest who are resuscitated

Exclusion Criteria:

  • Younger than 18 years old

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT00920244

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St.Olavs Hospital, Department of Anesthesia
Trondheim, Norway, 7014
Sponsors and Collaborators
St. Olavs Hospital
Norwegian Air Ambulance Foundation
Norwegian University of Science and Technology
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Study Chair: Eirik Skogvoll, MD, PhD St. Olavs Hospital
Principal Investigator: Trond Nordseth, MD St. Olavs Hospital

Publications of Results:
Publications automatically indexed to this study by Identifier (NCT Number):
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Responsible Party: St. Olavs Hospital Identifier: NCT00920244    
Other Study ID Numbers: 4.2008.2402 (REK)
08/11457 ( Other Identifier: SHDir )
20708/2/IB ( Other Identifier: NSD )
First Posted: June 15, 2009    Key Record Dates
Last Update Posted: September 5, 2018
Last Verified: August 2018
Keywords provided by St. Olavs Hospital:
Cardiac arrest
Additional relevant MeSH terms:
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Heart Arrest
Death, Sudden, Cardiac
Death, Sudden
Heart Diseases
Cardiovascular Diseases
Pathologic Processes
Epinephryl borate
Adrenergic alpha-Agonists
Adrenergic Agonists
Adrenergic Agents
Neurotransmitter Agents
Molecular Mechanisms of Pharmacological Action
Physiological Effects of Drugs
Adrenergic beta-Agonists
Bronchodilator Agents
Autonomic Agents
Peripheral Nervous System Agents
Anti-Asthmatic Agents
Respiratory System Agents
Vasoconstrictor Agents
Adjuvants, Anesthesia
Anti-Arrhythmia Agents