The Duration of Humoral Immunity and the Memory Cell Function After Vaccination With 7-valent Pneumococcal Conjugate Vaccine in CLL (KLL2)
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|ClinicalTrials.gov Identifier: NCT00919321|
Recruitment Status : Completed
First Posted : June 12, 2009
Last Update Posted : February 19, 2014
Patients with chronic lymphocytic leukemia (CLL)have had very poor humoral responses to pneumococcal polysaccharide vaccine (PPV). The vaccine in which pneumococcal polysaccharide antigens are conjugated to protein (PCV) have been immunogenic in CLL patients in our previous studies.
The purpose of this study is to evaluate the duration of these vaccine-induced antibodies and the function of memory cells by giving a one dose of PPV-vaccine after several years of PCV-vaccination.
|Condition or disease||Intervention/treatment||Phase|
|Chronic Lymphocytic Leukemia (CLL)||Biological: Pneumococcal polysaccharide vaccine (PPV)||Phase 4|
|Study Type :||Interventional (Clinical Trial)|
|Actual Enrollment :||32 participants|
|Intervention Model:||Single Group Assignment|
|Masking:||None (Open Label)|
|Study Start Date :||June 2009|
|Primary Completion Date :||December 2013|
|Study Completion Date :||December 2013|
Biological: Pneumococcal polysaccharide vaccine (PPV)
One intramuscular injection
- Antibody response [ Time Frame: 1-3 months ]
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00919321
|Tampere University Hospital|
|Tampere, Finland, FIN 33521|