Pilot Study of Hippocampal Function in Type 1 Diabetes Mellitus (T1DM) (ASSET)

This study is ongoing, but not recruiting participants.
Information provided by (Responsible Party):
Washington University School of Medicine
ClinicalTrials.gov Identifier:
First received: June 8, 2009
Last updated: January 7, 2016
Last verified: January 2016
This study is an expansion of a previous study done to determine how thinking skills relate to hypoglycemia (low blood sugar) and certain regions of the brain in children and adolescents. In this study, the investigators are testing thinking skills and measuring brain activity in adolescents with and without type 1 diabetes mellitus.

Type 1 Diabetes Mellitus

Study Type: Observational
Study Design: Observational Model: Case Control
Time Perspective: Prospective
Official Title: Pilot Study of Hippocampal Function in T1DM

Resource links provided by NLM:

Further study details as provided by Washington University School of Medicine:

Enrollment: 91
Study Start Date: April 2007
Estimated Study Completion Date: December 2016
Primary Completion Date: December 2013 (Final data collection date for primary outcome measure)
Type 1 Diabetes Mellitus
Adolescents ages 13-18 with T1DM
Non Controls
Healthy adolescents ages 13-18 without T1DM


Ages Eligible for Study:   13 Years to 18 Years
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population
Young adults will be piloted in a sample of diabetic and non-diabetic adolescents ages 13-18.

Inclusion Criteria:

  • Age 13 - 18
  • Right handed
  • Diagnosis of Type 1 Diabetes OR normal sibling control
  • If diabetic, then diagnosis for at least 2 years

Exclusion Criteria:

  • Pregnant or lactating
  • Chronic disease other than well-controlled asthma, or Hashimoto's thyroiditis.
  • Other current serious medical illness
  • Co-morbid psychiatric illness
  • Co-morbid neurological illness
  • Pre-maturity at birth
  • Contraindication to MRI scan
  • orthodontic braces.
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT00918801

United States, Missouri
Washington University School of Medicine
St. Louis, Missouri, United States, 63110
Sponsors and Collaborators
Washington University School of Medicine
Principal Investigator: Tamara G Hershey, PhD. Washington University School of Medicine
  More Information

Additional Information:
Responsible Party: Washington University School of Medicine
ClinicalTrials.gov Identifier: NCT00918801     History of Changes
Other Study ID Numbers: 06-0786 
Study First Received: June 8, 2009
Last Updated: January 7, 2016
Health Authority: United States: Institutional Review Board

Keywords provided by Washington University School of Medicine:

Additional relevant MeSH terms:
Diabetes Mellitus
Diabetes Mellitus, Type 1
Autoimmune Diseases
Endocrine System Diseases
Glucose Metabolism Disorders
Immune System Diseases
Metabolic Diseases

ClinicalTrials.gov processed this record on May 24, 2016