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Effect of Mitomycin C on Urethral Stricture Recurrence After Internal Urethrotomy

The recruitment status of this study is unknown. The completion date has passed and the status has not been verified in more than two years.
Verified June 2009 by Hillel Yaffe Medical Center.
Recruitment status was:  Not yet recruiting
Information provided by:
Hillel Yaffe Medical Center Identifier:
First received: June 9, 2009
Last updated: June 10, 2009
Last verified: June 2009
The aim of this study is to evaluate the efficacy of local injected mitomycin C at the time of internal urethrotomy in order to prevent the recurrence of urethral strictures.

Condition Intervention Phase
Urethral Stricture
Procedure: Internal urethrotomy
Drug: Mitomycin C - local injection
Phase 1
Phase 2

Study Type: Interventional
Study Design: Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Open Label
Primary Purpose: Treatment

Resource links provided by NLM:

Further study details as provided by Hillel Yaffe Medical Center:

Primary Outcome Measures:
  • Urethral stricture recurrence [ Time Frame: One year ]

Study Start Date: June 2009
Arms Assigned Interventions
Active Comparator: 1. Internal urethrotomy Procedure: Internal urethrotomy
Experimental: 2. Internal urethrotomy + mitomycin C Procedure: Internal urethrotomy Drug: Mitomycin C - local injection


Ages Eligible for Study:   18 Years to 85 Years   (Adult, Senior)
Sexes Eligible for Study:   Male
Accepts Healthy Volunteers:   No

Inclusion Criteria:

  • Male urethral stricture suitable for internal urethrotomy
  • Stricture length less than 10 mm

Exclusion Criteria:

  • Stricture length over 10 mm
  • Benign prostate enlargement
  Contacts and Locations
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Please refer to this study by its identifier: NCT00918528

Hillel Yaffe Medical Center Not yet recruiting
Hadera, Israel, 38100
Contact: Michael Mullerad, MD    972-4-630-4440      
Contact: Nachum Erlich, MD    972-4-630-4440   
Principal Investigator: Michael Mullerad, MD         
Principal Investigator: Nachum Erlich, MD         
Sponsors and Collaborators
Hillel Yaffe Medical Center
  More Information

Responsible Party: Nachum Erlich, Hillel Yaffe Medical Center Identifier: NCT00918528     History of Changes
Other Study ID Numbers: 0020-09-HYMC
Study First Received: June 9, 2009
Last Updated: June 10, 2009

Keywords provided by Hillel Yaffe Medical Center:
Urethral stricture
Mitomycin C
Internal Urethrotomy

Additional relevant MeSH terms:
Constriction, Pathologic
Urethral Stricture
Pathological Conditions, Anatomical
Urethral Obstruction
Urethral Diseases
Urologic Diseases
Antibiotics, Antineoplastic
Antineoplastic Agents
Alkylating Agents
Molecular Mechanisms of Pharmacological Action
Nucleic Acid Synthesis Inhibitors
Enzyme Inhibitors processed this record on May 24, 2017