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Structure and Function of Salivary Proteins

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ClinicalTrials.gov Identifier: NCT00916682
Recruitment Status : Unknown
Verified June 2009 by Boston Children’s Hospital.
Recruitment status was:  Recruiting
First Posted : June 9, 2009
Last Update Posted : June 9, 2009
Sponsor:
Collaborators:
Tufts University
Boston University
Boston Medical Center
University of North Carolina, Chapel Hill
Ahura Scientific, Inc.
Information provided by:
Boston Children’s Hospital

Brief Summary:
This study seeks to provide point-of-care clinical diagnostic systems for the diagnosis of current disease status using saliva as a sample specimen.

Condition or disease
Cystic Fibrosis

Detailed Description:
The overall hypothesis of this study is that whole saliva and its components, due to its direct anatomic relation to the airways, provides a window on the composition and nature of the disease-specific response in the bronchial, sinus, and nasal airways. By examining proteins created in saliva, we hope to validate that saliva is an important diagnostic tool for for rapid analysis of respiratory status. We further propose that rapid salivary diagnostics will improve patient care in prevalent respiratory diseases with frequent health care utilization and high morbidity, such as asthma, chronic obstructive pulmonary disease (COPD), and cystic fibrosis (CF).

Study Type : Observational
Estimated Enrollment : 200 participants
Observational Model: Case Control
Time Perspective: Prospective
Official Title: Structure and Function of Salivary Proteins
Study Start Date : November 2007
Estimated Primary Completion Date : February 2010

Resource links provided by the National Library of Medicine

MedlinePlus related topics: Cystic Fibrosis
U.S. FDA Resources

Group/Cohort
Cystic Fibrosis




Information from the National Library of Medicine

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Ages Eligible for Study:   6 Years and older   (Child, Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population
Subjects will be approached during their pulmonary clinic appointment or while they are inpatient at Children's Hospital, Boston.
Criteria

Inclusion Criteria:

  • 6 or more years of age
  • confirmed Cystic Fibrosis

Exclusion Criteria:

  • Pregnant

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00916682


Contacts
Contact: Lamia Momen 617-355-6665 lamia.momen@childrens.harvard.edu

Locations
United States, Massachusetts
Children's Hosptital, Boston Recruiting
Boston, Massachusetts, United States, 02115
Contact: Lamia Momen    617-355-6665    lamia.momen@childrens.harvard.edu   
Principal Investigator: Ahmet Uluer, DO         
Sponsors and Collaborators
Boston Children’s Hospital
Tufts University
Boston University
Boston Medical Center
University of North Carolina, Chapel Hill
Ahura Scientific, Inc.
Investigators
Principal Investigator: Ahmet Uluer, DO Boston Children’s Hospital

Additional Information:
Responsible Party: Ahmet Uluer, DO, Children's Hospital, Boston
ClinicalTrials.gov Identifier: NCT00916682     History of Changes
Other Study ID Numbers: X07-03-0142
First Posted: June 9, 2009    Key Record Dates
Last Update Posted: June 9, 2009
Last Verified: June 2009

Additional relevant MeSH terms:
Cystic Fibrosis
Pancreatic Diseases
Digestive System Diseases
Lung Diseases
Respiratory Tract Diseases
Genetic Diseases, Inborn
Infant, Newborn, Diseases