Prokinetic Drugs and Enteral Nutrition (prokinetics)

The recruitment status of this study is unknown because the information has not been verified recently.
Verified June 2009 by Universitair Ziekenhuis Brussel.
Recruitment status was  Not yet recruiting
Information provided by:
Universitair Ziekenhuis Brussel Identifier:
First received: June 5, 2009
Last updated: NA
Last verified: June 2009
History: No changes posted
The purpose of this study is to compare the effect of two drugs that can help in the prevention of regurgitation during the administration of enteral nutrition and define which one is the most effective.

Critically Ill
Enteral Nutrition

Study Type: Observational
Study Design: Observational Model: Cohort
Time Perspective: Prospective
Official Title: Effect of Prokinetic Drugs During the Administration of Enteral Nutrition

Further study details as provided by Universitair Ziekenhuis Brussel:

Estimated Enrollment: 60
Study Start Date: September 2009
Detailed Description:
Two prokinetic drugs (metoclopramide and erythromycin) will be compared during the administration of enteral nutrition in critically ill patients. We would like to know which one is the most effective in preventing regurgitation and risk of aspiration, which is a common complication of enteral nutritional support. This will be evaluated by measuring gastric residue every six hours.

Ages Eligible for Study:   18 Years and older
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population
Critically ill patients, intubated and mechanically ventilated, 18 years or older

Inclusion Criteria:

  • critically ill patients
  • intubated
  • mechanically ventilated
  • 18 or older age
  • enterally fed

Exclusion Criteria:

  • prokinetic drugs before start study
  • allergy to study medication
  • interactions odf study medication with other drugs
  • recent gastro-intestinal surgery
  • history of esophagectomy or gastrectomy
  • suspicion of gastrointestinal perforation
  • myasthenia gravis
  • liver dysfunction
  • less than 7 days in study
  • gastro- or jejunostomy
  Contacts and Locations
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Please refer to this study by its identifier: NCT00916591

Contact: Nele Van De Winkel 00324773348

UZBrussels Not yet recruiting
Jette, Belgium, 1090
Contact: Nele Van De Winkel, MD    00324773348   
Principal Investigator: Nele Van De Winkel, MD         
Sponsors and Collaborators
Universitair Ziekenhuis Brussel
  More Information

Responsible Party: Van De Winkel Nele MD, UZBrussels Identifier: NCT00916591     History of Changes
Other Study ID Numbers: UZBrussels  2009-012342-23 
Study First Received: June 5, 2009
Last Updated: June 5, 2009
Health Authority: Belgium: Federal Agency for Medicinal Products and Health Products

Keywords provided by Universitair Ziekenhuis Brussel:
gastroesophageal reflux
respiratory aspiration

Additional relevant MeSH terms:
Critical Illness
Disease Attributes
Pathologic Processes processed this record on May 22, 2016