Investigation of the Effects of Exercise on Gene Expression

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT00916019
Recruitment Status : Completed
First Posted : June 8, 2009
Last Update Posted : June 16, 2009
Information provided by:
Fukuoka University

Brief Summary:
The investigators have previously shown that mild exercise training at the level of lactate threshold (LT) intensity (60 min/day, 5 days/week) improves peripheral insulin sensitivity and insulin-independent glucose disposal of glucose effectiveness, without changes in body weight and body fat (Nishida et al, Diabetes Care, 2001; Nishida et al, Diabetes, 2004). Thus these beneficial effects are likely related to a number of adaptations that occur in skeletal muscle as response to exercise. In the current study, the investigators hypothesised that a single bout of mild exercise performed at LT would be a physiological stimulator of skeletal muscle PGC-1alpha gene, and the repetition of this exercise stimulating PGC-1alpha gene (i.e., training) for 12 weeks would induce coordinated increases in a large number of metabolic genes, as well as other genes potentially important in the prevention of insulin resistance and metabolic syndrome.

Condition or disease Intervention/treatment Phase
Healthy Other: exercise training Not Applicable

Study Type : Interventional  (Clinical Trial)
Actual Enrollment : 6 participants
Intervention Model: Single Group Assignment
Masking: None (Open Label)
Primary Purpose: Basic Science
Official Title: Investigation on Gene Expression and Gene Marker Accompanied by a Single Bout of Exercise and Exercise Training
Study Start Date : July 2002
Actual Primary Completion Date : December 2007
Actual Study Completion Date : December 2007

Resource links provided by the National Library of Medicine

U.S. FDA Resources

Arm Intervention/treatment
Experimental: exercise
mild exercise training
Other: exercise training
60 min of low-intensity exercise, 5 days/week, 12 weeks

Primary Outcome Measures :
  1. Skeletal muscle PGC-1alpha gene expression and mitochondrial gene expression [ Time Frame: 3 months ]

Information from the National Library of Medicine

Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.

Ages Eligible for Study:   19 Years to 32 Years   (Adult)
Sexes Eligible for Study:   Male
Accepts Healthy Volunteers:   Yes

Inclusion Criteria:

  • Men who were all in good health
  • All individuals were free from diabetes and none were taking any medications
  • All subjects were asked not to change their normal dietary habits, and not to engage in any strenuous physical activity

Exclusion Criteria:

  • People who undergone regular exercise for at least 2 years
  • Smokers

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT00916019

Fukuoka University
Fukuoka, Japan, 814-0133
Sponsors and Collaborators
Fukuoka University
Principal Investigator: Hiroaki Tanaka, Ph.D. Fukuoka University

Responsible Party: Hiroaki Tanaka, Ph.D, Fukuoka University Identifier: NCT00916019     History of Changes
Other Study ID Numbers: 19200049
First Posted: June 8, 2009    Key Record Dates
Last Update Posted: June 16, 2009
Last Verified: June 2009

Keywords provided by Fukuoka University:
gene expression
skeletal muscle
Healthy men