Meal Stimulating After Roux-en Y Gastric Bypass
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|ClinicalTrials.gov Identifier: NCT00915980|
Recruitment Status : Completed
First Posted : June 8, 2009
Last Update Posted : July 8, 2011
In many studies, gastric bypass surgery led to total remission of type 2 diabetes (T2DM) as early as 1 - 2 days after surgery before any real weight loss has occurred. This suggests that the remission of the T2DM is due to the direct effect of the operation, more than the secondary effect of the weight loss. The reasons for the major effect on the glucose metabolism after gastric bypass surgery are still unaccounted for.
The aim of this project will be to unveil some of the mechanisms that explain the effect of gastric bypass surgery on the glucose metabolism. Further more to find a better way of testing patients that have just undergone gastric bypass surgery. It is not possible to test patients who have just undergone gastric bypass surgery with normal oral glucose tolerance test (OGTT) and a normal meal, because patients can only take in fluid and a normal OGTT will often lead to dumping. Instead we will try to modify these tests - OGTT with lower glucose level and meal-testing with a protein drink.
The hypothesis of the study is that the investigators can see changes in different hormones and adipokines before and after surgery, even with modified OGTT and meal testing. The project will consist of clinical trials on patients without T2DM that will undergo gastric bypass surgery. The studies will take place before and within the first week after surgery. The investigators will measure different hormones and adipokines after OGTT and a meal with a protein drink. The investigators expect to see significant changes in some of the analyses after the operation in patients undergoing gastric bypass.
|Condition or disease||Intervention/treatment|
|Gastric Bypass Obesity||Procedure: gastric bypass surgery and testing|
|Study Type :||Observational|
|Actual Enrollment :||8 participants|
|Official Title:||Meal Stimulating After Roux-en Y Gastric Bypass|
|Study Start Date :||January 2008|
|Primary Completion Date :||May 2009|
|Study Completion Date :||October 2010|
|Patients without diabetes undergoing gastric bypass||
Procedure: gastric bypass surgery and testing
The patients will be tested with OGTT and meal testing before and after undergoing gastric bypass surgery.
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00915980
|Hvidovre, Denmark, 2650|