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Prevention of Potentially Inappropriate Prescribing in Late Life Using Screening Tool of Older Persons' Potentially Inappropriate Prescriptions (STOPP) and Screening Tool to Alert Doctors to Right Treatment (START) Criteria

The recruitment status of this study is unknown. The completion date has passed and the status has not been verified in more than two years.
Verified October 2009 by Cork University Hospital.
Recruitment status was:  Active, not recruiting
Information provided by:
Cork University Hospital Identifier:
First received: June 4, 2009
Last updated: October 28, 2009
Last verified: October 2009

Potentially inappropriate prescribing is common in older patients and encompasses overuse, misuse and underuse of medications. Potentially inappropriate prescribing is associated with negative outcomes including adverse drug events and hospitalization.

STOPP (Screening Tool of Older Person's potentially inappropriate Prescriptions) and START (Screening Tool to Alert doctors to Right Treatment) is a new screening tool designed to detect instances of potentially inappropriate medication use and under-prescribing of clinically indicated medications in older patients. The purpose of this study is to determine whether clinical implementation of STOPP/START criteria in hospitalized older patients is effective in improving prescribing quality.

Condition Intervention Phase
Other: STOPP/START criteria
Phase 4

Study Type: Interventional
Study Design: Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Open Label
Official Title: Prevention of Potentially Inappropriate Prescribing in Late Life Using STOPP (Screening Tool of Older Persons' Potentially Inappropriate Prescriptions) and START (Screening Tool to Alert Doctors to Right i.e. Appropriate Indicated Treatment): A Randomized Controlled Trial.

Further study details as provided by Cork University Hospital:

Primary Outcome Measures:
  • Appropriateness of prescribing using the Medication Appropriateness Index and the Assessment of Underutilization of Medication Tool [ Time Frame: Measured on admission, discharge and at 2, 4 and 6 months post-discharge ]

Secondary Outcome Measures:
  • Composite health resource utilization including hospital readmission and primary care consultations [ Time Frame: at 2, 4 and 6 months post-discharge ]

Enrollment: 400
Study Start Date: November 2007
Estimated Study Completion Date: June 2009
Primary Completion Date: June 2009 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Experimental: STOPP/START intervention
STOPP/START intervention group
Other: STOPP/START criteria
Application of STOPP/START criteria to the patient's prescription and diagnostic information with subsequent written recommendation on pharmaceutical care to the patient's medical team


Ages Eligible for Study:   65 Years and older   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes

Inclusion Criteria:

  • All patients aged 65 years and older admitted to the general medical services of Cork University Hospital, Cork, Ireland

Exclusion Criteria:

  • Patient admitted to a geriatric medicine service, psychiatry of old age service or clinical pharmacology service, or under review of these services during the previous 12 months
  • Critically ill patient (admitted to the intensive care unit)
  • Terminally ill patient
  • Refusal of patient or hospital physician to participate
  • No time for the research physician to enrol the patient within 3 days of admission
  Contacts and Locations
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Please refer to this study by its identifier: NCT00915824

Cork University Hospital
Cork, Ireland
Sponsors and Collaborators
Cork University Hospital
Principal Investigator: Paul Gallagher, MB MRCPI Cork University Hospital
Study Director: Denis O'Mahony, MD FRCPI Cork University Hospital
  More Information

Responsible Party: Dr. Paul Gallagher, Clinical Research Fellow, Department of Geriatric Medicine, Cork University Hospital Identifier: NCT00915824     History of Changes
Other Study ID Numbers: CRT2006029
Study First Received: June 4, 2009
Last Updated: October 28, 2009

Keywords provided by Cork University Hospital:
Drug therapy
Randomized controlled trial
STOPP/START criteria
Appropriateness of prescribing in older patients
Prescription Drugs processed this record on April 28, 2017