Identification of Protective and Worsening Steatohepatitis (NASH) Factors
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ClinicalTrials.gov Identifier: NCT00914446
Verified June 2009 by Centre Hospitalier Universitaire de Nice. Recruitment status was: Recruiting
The main aim of this work will be to identify a profile of gene expression by microarray in the liver which might allow to differentiate obese subjects having a normal liver from those with steatohepatitis or steatosis.
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Ages Eligible for Study:
18 Years to 60 Years (Adult)
Sexes Eligible for Study:
Accepts Healthy Volunteers:
Inclusion Criteria for morbid obese subjects without diabetes:
18-60 years old, male or female
Body mass index > 40 kg/m2
Obesity surgery required
Alcohol consumption < 20g per day
Affiliation to national French health insurance
Hepatitis B, C, HIV
Pregnant or breast-feeding woman.
Inability to sign informed consent
Patient with regulatory authority patient gold private freedom
Inclusion criteria for controls subjects:
Subjects of the 2 sexes of 18-60 years old
Patients with normal body mass index between 20-25 kg/m2
Patients profiting from hepatectomy for benign tumors like adenoma or bulky tumor hepatic biliary cyst or from a repair of the abdominal wall
Subjects affiliated to a mode of social security
Patient having signed the enlightened consent
The private subjects from freedom and the major subjects under supervision will be excluded
Inclusion criteria for overweight and NASH subjects: