The Effects of Continuous Positive Airway Pressure on Overlap Syndrome
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|ClinicalTrials.gov Identifier: NCT00914264|
Recruitment Status : Unknown
Verified August 2010 by Chang Gung Memorial Hospital.
Recruitment status was: Recruiting
First Posted : June 4, 2009
Last Update Posted : February 5, 2015
- The first objective of this study is to determine the differences between, while the airway obstruction severity is the same, and the acute continuous positive airway pressure (CPAP) effect on chronic obstructive pulmonary disease (COPD) patients with overlap syndrome compared with COPD patients without in terms of sleep quality, autonomic nerve activity, biologic markers of systemic inflammatory, and exercise performance.
- The second objective of this study is to evaluate the subacute (3 months treatment) CPAP effect on COPD patients with overlap syndrome in terms of pulmonary hemodynamic and right heart function, We will also determine the subacute effect of CPAP on sleep and life quality, autonomic nerve activity, biologic markers of systemic inflammatory, as well as exercise performance.
- The last objective of this study is to evaluate the long term (12 months treatment) CPAP effect on COPD patients with overlap syndrome. The un-scheduled clinic or emergency department visiting, hospitalization, or mortality will be recorded to see if there is significant treatment effect in terms of reducing morbidity and mortality. The long term CPAP effect on sleep and life quality, autonomic nerve activity, biologic markers of systemic inflammatory, exercise performance, as well as pulmonary hemodynamic and right heart function will be re-evaluation.
|Condition or disease||Intervention/treatment|
|COPD & OSA||Device: continuous positive airway pressure|
|Study Type :||Observational|
|Estimated Enrollment :||90 participants|
|Official Title:||The Continuous Positive Airway Pressure Effects on Chronic Obstructive Pulmonary Disease Patients With Obstructive Sleep Apnea|
|Study Start Date :||December 2008|
|Estimated Primary Completion Date :||July 2015|
|Estimated Study Completion Date :||December 2015|
COPD with OSA with CPAP treatment
COPD with OSA: CPAP treatment
Device: continuous positive airway pressure
CPAP with adequate pressure for 1 day, 3 & 12 months
COPD without OSA
COPD without OSA, not treat with CPAP
COPD with OSA but without CPAP treatment
COPD with OSA but patient refused CPAP treatment
- exercise performance [ Time Frame: 3 days, 3 & 12 months ]the condition of COPD patient will be disturbed by season factor 12 months follow up will be better than 18 months
- autonomic nerve activity [ Time Frame: 3 days, 3 & 12 months ]the same reason as above
- mortality and acute exacerbation [ Time Frame: 1, 5, 10 years ]
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00914264
|Contact: Tsai-Yu Wang, MD||886-3-3281200 ext firstname.lastname@example.org|
|Contact: Yu-Lun Lo, MD||886-3-3281200 ext email@example.com|
|Division of Thoracic Medicine, Chang Gung Memorial Hospital||Recruiting|
|Taipei, Taiwan, 105|
|Study Director:||Yu-Lun Lo, MD||Department of Thoracic Medicine, Chang Gung Memorial Hospital, Taipei, Taiwan|
|Principal Investigator:||Tsai-Yu Wang, MD||Department of Thoracic Medicine, Chang Gung Memorial Hospital, Taipei, Taiwan|
|Study Chair:||Han-Pin Kuo, MD,PHD||Department of Thoracic Medicine, Chang Gung Memorial Hospital, Taipei, Taiwan|