Liver Regeneration Therapy Using Autologous Adipose Tissue Derived Stromal Cells
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Mesenchymal stem cells have the capability to differentiate into hepatocytes and will be useful for liver regeneration. Adipose tissue is relatively enriched with mesenchymal stem cells compared to bone marrow tissue. In this trial, eligible liver cirrhosis patients will receive autologous adipose tissue derived stromal cells which include such mesenchymal stem cells.
Condition or disease
Biological: adipose tissue derived stromal cells
The population of the liver cirrhosis patients is enormous in Japan and the only radical treatment for them is liver transplantation. However, the number of giving donors is extremely limited. Mesenchymal stem cells have been capable to differentiate into mesodermal-lineage cells as well as endodermal-lineage cells such as hepatocytes. They reside in the mesenchymal tissues such as bone marrows as well as adipose tissues. The latter tissues are relatively enriched with mesenchymal stem cells compared to bone marrow cells. In this study, the cirrhotic patients will receive autologous adipose tissue derived stromal cells which contains substantial number of mesenchymal stem cells.
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Ages Eligible for Study:
20 Years to 80 Years (Adult, Senior)
Sexes Eligible for Study:
Accepts Healthy Volunteers:
Liver cirrhosis patients
Platelets count in peripheral blood: over 7.0x10^4/microliter
Serum creatinine: less than 1.5 mg/dl
Capable of understanding the features of this clinical trial
Associated with risky gastroesophageal varices for bleeding
Severe portal hypertension
Complicated with severe heart failure
Coagulation disturbance and judged to be excluded by doctors