Repetitive Transcranial Magnetic Stimulation (rTMS) to Promote Hand Recovery in Stroke (rTMS)
|ClinicalTrials.gov Identifier: NCT00913211|
Recruitment Status : Completed
First Posted : June 4, 2009
Last Update Posted : August 31, 2011
|Condition or disease||Intervention/treatment||Phase|
|Stroke||Device: rTMS Procedure: Motor learning training Procedure: rTMS and Tracking Device: Sham rTMS||Phase 1|
Show Detailed Description
|Study Type :||Interventional (Clinical Trial)|
|Estimated Enrollment :||40 participants|
|Intervention Model:||Parallel Assignment|
|Official Title:||rTMS and Motor Learning Training to Promote Recovery From Hemiparesis|
|Study Start Date :||September 2007|
|Primary Completion Date :||August 2011|
|Study Completion Date :||August 2011|
Experimental: rTMS only
brain stimulation to non-stroke primary motor area
600 pulses of 6 hz priming rTMS at 90% of threshold followed by 600 pulses of low-frequency rTMS at 90% of threshold.
Experimental: Finger tracking training
Motor learning training using finger flexion/extension tracking movements toward a target.
Procedure: Motor learning training
one hour of repeated finger tracking movements toward a changing target.
Experimental: rTMS and finger tracking
Combination of rTMS and tracking
Procedure: rTMS and Tracking
Combination of rTMS and finger tracking
Placebo Comparator: Sham
Sham rTMS treatment
Device: Sham rTMS
Sham treatment of rTMS
- box and block finger prehension test [ Time Frame: 45 days ]
- cortical excitability [ Time Frame: from pretest to posttest (2 weeks) ]Paired pulse TMS testing will show increase in the ratio of paired pulse to single pulse MEP amplitude when stimulating ipsilesional M1.
- cognitive function [ Time Frame: pretest to posttest (2 weeks) ]There will be no decline in function on the Hopkins Verbal learning test.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00913211
|United States, Minnesota|
|University of Minnesota|
|Minneapolis, Minnesota, United States, 55455|
|Principal Investigator:||James R Carey, PhD||University of Minnesota - Clinical and Translational Science Institute|