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Prospective Evaluation of Forceplate Measured Levodopa-Induced Dyskinesia

This study has been completed.
Information provided by (Responsible Party):
Kathryn Anne Chung, Oregon Health and Science University Identifier:
First received: June 2, 2009
Last updated: September 29, 2016
Last verified: September 2016
Nearly all Parkinson's disease (PD) patients eventually develop abnormal and unwanted movements (dyskinesias; LID) caused by the gold standard treatment, Levodopa. The severity of these movements can range from subtle to extremely debilitating and may or may not interfere with normal activities such as putting on a coat or brushing ones teeth. The purpose of this study is to demonstrate the validity and reliability of objectively measuring dyskinesia with a forceplate.

Parkinson's Disease

Study Type: Observational
Study Design: Observational Model: Case-Crossover
Time Perspective: Prospective
Official Title: Prospective Evaluation of Forceplate Measured Levodopa-Induced Dyskinesia

Resource links provided by NLM:

Further study details as provided by Oregon Health and Science University:

Primary Outcome Measures:
  • Forceplate Measure [ Time Frame: Every 1/2 hour ]

Secondary Outcome Measures:
  • Visual Rating Scale [ Time Frame: every 1/2 hour ]

Enrollment: 10
Study Start Date: June 2009
Study Completion Date: June 2010
Primary Completion Date: June 2010 (Final data collection date for primary outcome measure)
Group 1
Groups are defined by another study
Group 2
Groups are defined by another study
Group 3
Groups are defined by another study

Detailed Description:
The main outcome measure of this study are measurements taken every half hour during an inpatient study visit. These measurements include standing on a forceplate for 1 minute while performing a mental task such as reciting the alphabet backwards. During this forceplate stance, a rater will visually score your movements. All participants must be eligible for another Parkinson's disease study at Oregon Health and Science University.

Ages Eligible for Study:   18 Years and older   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population
Parkinsons disease patients with levodopa-induced dyskinesia

Inclusion Criteria:

  • Parkinsons disease
  • Older than 18

Exclusion Criteria:

  • Must be participating in a Parkinsons disease study at Oregon Health & Science University
  Contacts and Locations
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Please refer to this study by its identifier: NCT00912977

United States, Oregon
Oregon Health & Science University
Portland, Oregon, United States, 97201
Sponsors and Collaborators
Oregon Health and Science University
Principal Investigator: Kathryn Chung, MD Oregon Health and Science University
  More Information

Responsible Party: Kathryn Anne Chung, Associate Professor, Oregon Health and Science University Identifier: NCT00912977     History of Changes
Other Study ID Numbers: e5348
Study First Received: June 2, 2009
Last Updated: September 29, 2016
Individual Participant Data  
Plan to Share IPD: Undecided

Keywords provided by Oregon Health and Science University:
Parkinsons disease

Additional relevant MeSH terms:
Parkinson Disease
Parkinsonian Disorders
Basal Ganglia Diseases
Brain Diseases
Central Nervous System Diseases
Nervous System Diseases
Movement Disorders
Neurodegenerative Diseases
Neurologic Manifestations
Signs and Symptoms
Antiparkinson Agents
Anti-Dyskinesia Agents
Dopamine Agents
Neurotransmitter Agents
Molecular Mechanisms of Pharmacological Action
Physiological Effects of Drugs processed this record on April 21, 2017