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Analyzing Composition and Lubrication Properties of Synovial Fluid (SFCL)

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ClinicalTrials.gov Identifier: NCT00912106
Recruitment Status : Completed
First Posted : June 3, 2009
Last Update Posted : June 3, 2009
Sponsor:
Collaborator:
National Science Concil
Information provided by:
Far Eastern Memorial Hospital

Study Description
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Brief Summary:
To analyze the relationship between composition of synovial fluid and its lubrication properties

Condition or disease Intervention/treatment
Knee Osteoarthritis HA Injection One Injection Per Week for Five Week Synovial Fluid Composition Synovial Fluid Lubrication Other: Synovial fluid composition and lubrication analysis

Detailed Description:
Patients suffering from serious arthritis may receive the artificial joint replacement surgery. Comparing to the articulation of articular cartilage, the artificial joint undergo a boundary lubrication in which a thin layer of synovial fluid molecules is formed between the artificial joint materials. Therefore a larger wear rate is observed in the artificial joint system. Researchers have devoted themselves to modifying the artificial joint materials in order to reduce the wear phenomena. We first propose that modification the lubrication by adding effective lubricating molecules may help to reduce the wear of artificial joint. However, there still lacks fundamentally understanding of the artificial joint lubrication mechanism under synovial fluid. Hence, we plan to investigate the boundary lubrication mechanism of synovial molecules, such as albumin, globulin, hyaluronic acid, and lipid in the first year. We would like to obtain the adsorption behaviors of the single molecules as well as multiple molecules on the surfaces of artificial joint materials by experiments. Molecular dynamics simulation will also be performed to gain the knowledge of adsorption energy and possible conformation change of the molecules. In the second year, the tribological heat and mechanical effects on the synovial molecules will be studied. The analysis platform will be established to perform the composition and properties measurement of the synovial molecules. In the third year, we will further discuss the effect of the synovial molecules transformation on the surrounding cells and tissues. Their influences on the tribological and biochemical behaviors will be investigated.
Study Design
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Study Type : Observational
Actual Enrollment : 55 participants
Observational Model: Case-Control
Time Perspective: Prospective
Official Title: Boundary Lubrication of Synovial Fluid Molecules and Its Effect on the Surrounding Cells and Tissues
Study Start Date : April 2008
Actual Primary Completion Date : December 2008
Actual Study Completion Date : June 2009

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Groups and Cohorts
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Group/Cohort Intervention/treatment
HA injection
Patients with osteoarthritis of knee. They are going to received HA injection 1 vial per week for 5 weeks.
 Other: Synovial fluid composition and lubrication analysis
Before HA injection, synovial fluid must be drawn to increase treatment effectiveness. The drawn synovial fluid was then analyzed in the lab. There was no influence for patients enrolled because the drawn synovial fluid would usually be discarded.


Outcome Measures
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Primary Outcome Measures :
  1. Synovial fluid HA and albumin concentration; synovial fluid lubrication [ Time Frame: 1 wk, 2 wk, 3 wk, 4 wk, 5 wk ]

Biospecimen Retention:   Samples Without DNA
synovial fluid from knee joint

Eligibility Criteria
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Ages Eligible for Study:   Child, Adult, Older Adult
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Probability Sample
Study Population
Patients who are going to receive HA injection of one or two knees
Criteria

Inclusion Criteria:

  • Patients who are going to receive HA injection of one or two knees

Exclusion Criteria:

  • Patients whose quantity of synovial fluid is not enough to be drawn
Contacts and Locations
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To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00912106


Locations
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Taiwan
Far Eastern Memorial Hospital
Pan-Ciao, Taipei, Taiwan, 22050
Sponsors and Collaborators
Far Eastern Memorial Hospital
National Science Concil
Investigators
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Study Director: Chih-Hung Chang, Ph. D Far Eastern Memorial Hospital
More Information
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Responsible Party: Chih-Hung Chang, Division of Orthopedics, Far Eastern Memorial Hospital
ClinicalTrials.gov Identifier: NCT00912106    
Other Study ID Numbers: 96024
NSC-96-
First Posted: June 3, 2009    Key Record Dates
Last Update Posted: June 3, 2009
Last Verified: June 2009
Keywords provided by Far Eastern Memorial Hospital:
osteoarthritis
HA
synovial fluid
lubrication
Additional relevant MeSH terms:
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Osteoarthritis
Osteoarthritis, Knee
Arthritis
 Joint Diseases
Musculoskeletal Diseases
Rheumatic Diseases