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Does APOE-e4 Predict Delirium and Cognitive Dysfunction After Surgery?

This study has been completed.
Canadian Anesthesiologists' Society
University of Ottawa
Information provided by:
Ottawa Hospital Research Institute Identifier:
First received: May 29, 2009
Last updated: NA
Last verified: May 2009
History: No changes posted
Patients with the APOE-ε4 genotype are at increased risk of both vascular dementia and peripheral vascular disease. Patients undergoing major vascular surgery are at particularly high risk of delirium and other, more subtle, changes in cognitive function following surgery. The hypothesis of this trial is that the APOE-ε4 genotype is associated with both delirium and postoperative cognitive dysfunction (POCD).

Postoperative Cognitive Dysfunction

Study Type: Observational
Study Design: Observational Model: Cohort
Time Perspective: Prospective
Official Title: Does Apolipoprotein E Genotype Predict Delirium and Postoperative Cognitive Dysfunction?

Resource links provided by NLM:

Further study details as provided by Ottawa Hospital Research Institute:

Primary Outcome Measures:
  • Delirium as assessed by the Confusion Assessment Method [ Time Frame: 7 days postoperatively ]

Secondary Outcome Measures:
  • POCD as assessed by a battery of 9 neuropsychometric tests [ Time Frame: 7 days postoperatively ]
  • POCD as assessed by a battery of 9 neuropsychometric tests [ Time Frame: 3 months postoperatively ]

Enrollment: 100
Study Start Date: August 2005
Study Completion Date: May 2009
Primary Completion Date: March 2008 (Final data collection date for primary outcome measure)
Open Aortic Repair
Patients 60 years of age and older undergoing open repair of the abdominal aorta


Ages Eligible for Study:   60 Years and older   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population
Patients 60 years of age or greater undergoing open repair of the abdominal aorta at an academic tertiary care hospital.

Inclusion Criteria:

  • Age 60 or greater
  • Open repair of the abdominal aorta

Exclusion Criteria:

  • refusal;
  • planned endovascular repair;
  • emergency surgery;
  • previous diagnosis of dementia, Parkinson's disease, or psychiatric illness;
  • active alcohol or substance abuse; and
  • physical inability to complete neuropsychometric testing.
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Please refer to this study by its identifier: NCT00911677

Canada, Ontario
The Ottawa Hospital - Civic Campus
Ottawa, Ontario, Canada, K1Y 4E9
Sponsors and Collaborators
Ottawa Hospital Research Institute
Canadian Anesthesiologists' Society
University of Ottawa
Principal Investigator: Gregory L Bryson, MD, FRCPC Department of Anesthesiology, The Ottawa Hospital
  More Information

Publications automatically indexed to this study by Identifier (NCT Number):
Responsible Party: Gregory L Bryson, Department of Anesthesiology, The Ottawa Hospital Identifier: NCT00911677     History of Changes
Other Study ID Numbers: OHREB 2004800-01H
Study First Received: May 29, 2009
Last Updated: May 29, 2009

Keywords provided by Ottawa Hospital Research Institute:
Delirium (MeSH Unique ID D003693)
Cognition Disorders (MeSH Unique ID D003072)
Postoperative Complications (MeSH Unique ID D011183)
Apolipoproteins E (MeSH Unique ID D001057)

Additional relevant MeSH terms:
Cognition Disorders
Neurobehavioral Manifestations
Neurologic Manifestations
Nervous System Diseases
Signs and Symptoms
Neurocognitive Disorders
Mental Disorders processed this record on May 25, 2017