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Gut Hormone Response, Appetite and Intestinal Transit Time in Good and Poor Weight Responders After Gastric Bypass (RnonR)

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ClinicalTrials.gov Identifier: NCT00908973
Recruitment Status : Completed
First Posted : May 27, 2009
Last Update Posted : March 20, 2012
Sponsor:
Collaborators:
University of Copenhagen
Novo Nordisk A/S
Information provided by (Responsible Party):
Carsten Dirksen, Hvidovre University Hospital

Brief Summary:
The aim of the study is to describe differences in meal-stimulated gut hormone response, appetite and intestinal transit time between good and poor responders 1-2 years after Gastric Bypass surgery for obesity.

Condition or disease
Obesity

Study Type : Observational
Actual Enrollment : 46 participants
Observational Model: Case Control
Time Perspective: Prospective
Official Title: Gut Hormone Response, Appetite and Intestinal Transit Time in Good and Poor Weight Responders 1-2 Years After Gastric Bypass
Study Start Date : May 2009
Actual Primary Completion Date : June 2011
Actual Study Completion Date : December 2011

Resource links provided by the National Library of Medicine

MedlinePlus related topics: Hormones
U.S. FDA Resources

Group/Cohort
Good responders
Excess weight loss of > 60% 1 year after gastric bypass surgery
Poor responders
Excess weight loss of =< 50% 1 year after gastric bypass surgery
Lean controls
Non-gastric bypass operated lean individuals, matched for age and sex



Biospecimen Retention:   Samples Without DNA
Plasma and serum specimens are retained


Information from the National Library of Medicine

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Ages Eligible for Study:   20 Years to 60 Years   (Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population
Case subjects are recruited from the outpatient clinic of endocrinology at Hvidovre University Hospital. Control subjects are recruited through announcement in local newspapers.
Criteria

Inclusion Criteria:

  • Age 20-60 years
  • Completed laparoscopic gastric bypass surgery without complications (cases)
  • No previous gastric bypass surgery (controls)

Exclusion Criteria:

  • Diabetes
  • Disease or treatment interfering with appetite or gastrointestinal motility
  • Pregnancy or breastfeeding
  • Excess weight loss 1 year after gastric bypass > 50% and =< 60% (cases)

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00908973


Locations
Denmark
Department of Endocrinology at Hvidovre University Hospital
Hvidovre, Copenhagen, Denmark, DK-2650
Sponsors and Collaborators
Hvidovre University Hospital
University of Copenhagen
Novo Nordisk A/S
Investigators
Principal Investigator: Carsten Dirksen, MD Dept. of Endocrinology, Hvidovre University Hospital, Hvidovre, Copenhagen, Denmark

Responsible Party: Carsten Dirksen, MD PhD student, Hvidovre University Hospital
ClinicalTrials.gov Identifier: NCT00908973     History of Changes
Other Study ID Numbers: RnonR
First Posted: May 27, 2009    Key Record Dates
Last Update Posted: March 20, 2012
Last Verified: March 2012

Keywords provided by Carsten Dirksen, Hvidovre University Hospital:
Obesity
Gastric bypass
Gut hormone
Intestinal transit time

Additional relevant MeSH terms:
Hormones
Hormones, Hormone Substitutes, and Hormone Antagonists
Physiological Effects of Drugs