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Metabolic Fate Modifications of Saturated Fats After an Overfeeding (SURNUT)

This study has been completed.
Sponsor:
ClinicalTrials.gov Identifier:
NCT00905892
First Posted: May 21, 2009
Last Update Posted: June 23, 2011
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
Collaborator:
Institut National de la Santé Et de la Recherche Médicale, France
Information provided by:
Centre de Recherche en Nutrition Humaine Rhone-Alpe
  Purpose
The purpose of this study is to determine the partitioning of exogenous lipids in the postprandial period while a study of overfeeding. The method is based on the incorporation of a stable isotopic tracer (d31_palmitic acid, d31_C16) in lipoprotein triglycerides (TG-CHYLOMICRON and TG-VLDL) and in free fatty acids (FFA).

Condition Intervention
Obesity Lipid Metabolism Inflammation Dietary Supplement: Hyperlipidic overfeeding

Study Type: Interventional
Study Design: Intervention Model: Single Group Assignment
Masking: None (Open Label)
Primary Purpose: Basic Science
Official Title: Metabolic Fate Modifications of Saturated Fats After an Overfeeding

Further study details as provided by Centre de Recherche en Nutrition Humaine Rhone-Alpe:

Primary Outcome Measures:
  • Post prandial partitioning of exogenous lipids [ Time Frame: Before and after overfeeding ]

Secondary Outcome Measures:
  • Genes expression in adipose and muscle tissues [ Time Frame: Before and after overfeeding ]

Estimated Enrollment: 40
Study Start Date: September 2005
Study Completion Date: March 2010
Primary Completion Date: December 2009 (Final data collection date for primary outcome measure)
Intervention Details:
    Dietary Supplement: Hyperlipidic overfeeding
    100g per day of cheese + 40g per day of almonds + 20g per day of butter
Detailed Description:
Healthy overweight and lean young men are subjected to an overfeeding during 56 days which corresponds to a supplement of 761 Kcal/day. During two exploration days (before : D0 et after : D56 overfeeding) they have ingested a breakfast with tracer (d31_palmitic acid, d31_C16, 20mg/kg) and blood and urine samples were collected every hour of each exploration day. The enrichment in deuterium was measured by gas chromatography-organic mass spectrometry (GC-OMS) in palmitic acid pool of lipid fractions.
  Eligibility

Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years to 55 Years   (Adult)
Sexes Eligible for Study:   Male
Accepts Healthy Volunteers:   Yes
Criteria

Inclusion Criteria:

  • 18 to 55 years old
  • BMI 18 to 30 kg/m²
  • Stable physical activity
  • Safety subject during medical consultation

Exclusion Criteria:

  • Medical or surgical history which may affect energy expenditure (renal -cardiovascular -hepatic- endocrine-inflammatory diseases)
  • Drug use that could affect energy expenditure (steroids, nicotine substitutes, thyroid hormones)
  • Eating disorder
  • Intensive sportive activity
  • Subjects who Smoke
  • Claustrophobic subjects
  Contacts and Locations
Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00905892


Locations
France
Centre de recherche en nutrition humaine Rhone-Alpes
Pierre-Bénite, France, 69495
Sponsors and Collaborators
Centre de Recherche en Nutrition Humaine Rhone-Alpe
Institut National de la Santé Et de la Recherche Médicale, France
Investigators
Study Director: Martine Laville, PhD, MD Centre de Recherche en Nutrition Humaine Rhône-Alpes
  More Information

Publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number):
Responsible Party: Martine Laville PhD, MD, CRNHRA
ClinicalTrials.gov Identifier: NCT00905892     History of Changes
Other Study ID Numbers: CRNHRA-09-002
First Submitted: May 20, 2009
First Posted: May 21, 2009
Last Update Posted: June 23, 2011
Last Verified: June 2011

Keywords provided by Centre de Recherche en Nutrition Humaine Rhone-Alpe:
overfeeding
stable isotopes
lipoprotein metabolism
lipid oxidation
fat distribution
gene expression
endotoxemia
mass spectrometry/gas chromatography

Additional relevant MeSH terms:
Inflammation
Pathologic Processes