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Metabolic Fate Modifications of Saturated Fats After an Overfeeding (SURNUT)

This study has been completed.
Institut National de la Santé Et de la Recherche Médicale, France
Information provided by:
Centre de Recherche en Nutrition Humaine Rhone-Alpe Identifier:
First received: May 20, 2009
Last updated: June 22, 2011
Last verified: June 2011
The purpose of this study is to determine the partitioning of exogenous lipids in the postprandial period while a study of overfeeding. The method is based on the incorporation of a stable isotopic tracer (d31_palmitic acid, d31_C16) in lipoprotein triglycerides (TG-CHYLOMICRON and TG-VLDL) and in free fatty acids (FFA).

Condition Intervention
Lipid Metabolism
Dietary Supplement: Hyperlipidic overfeeding

Study Type: Interventional
Study Design: Intervention Model: Single Group Assignment
Masking: Open Label
Primary Purpose: Basic Science
Official Title: Metabolic Fate Modifications of Saturated Fats After an Overfeeding

Further study details as provided by Centre de Recherche en Nutrition Humaine Rhone-Alpe:

Primary Outcome Measures:
  • Post prandial partitioning of exogenous lipids [ Time Frame: Before and after overfeeding ]

Secondary Outcome Measures:
  • Genes expression in adipose and muscle tissues [ Time Frame: Before and after overfeeding ]

Estimated Enrollment: 40
Study Start Date: September 2005
Study Completion Date: March 2010
Primary Completion Date: December 2009 (Final data collection date for primary outcome measure)
Intervention Details:
    Dietary Supplement: Hyperlipidic overfeeding
    100g per day of cheese + 40g per day of almonds + 20g per day of butter
Detailed Description:
Healthy overweight and lean young men are subjected to an overfeeding during 56 days which corresponds to a supplement of 761 Kcal/day. During two exploration days (before : D0 et after : D56 overfeeding) they have ingested a breakfast with tracer (d31_palmitic acid, d31_C16, 20mg/kg) and blood and urine samples were collected every hour of each exploration day. The enrichment in deuterium was measured by gas chromatography-organic mass spectrometry (GC-OMS) in palmitic acid pool of lipid fractions.

Ages Eligible for Study:   18 Years to 55 Years   (Adult)
Sexes Eligible for Study:   Male
Accepts Healthy Volunteers:   Yes

Inclusion Criteria:

  • 18 to 55 years old
  • BMI 18 to 30 kg/m²
  • Stable physical activity
  • Safety subject during medical consultation

Exclusion Criteria:

  • Medical or surgical history which may affect energy expenditure (renal -cardiovascular -hepatic- endocrine-inflammatory diseases)
  • Drug use that could affect energy expenditure (steroids, nicotine substitutes, thyroid hormones)
  • Eating disorder
  • Intensive sportive activity
  • Subjects who Smoke
  • Claustrophobic subjects
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Please refer to this study by its identifier: NCT00905892

Centre de recherche en nutrition humaine Rhone-Alpes
Pierre-Bénite, France, 69495
Sponsors and Collaborators
Centre de Recherche en Nutrition Humaine Rhone-Alpe
Institut National de la Santé Et de la Recherche Médicale, France
Study Director: Martine Laville, PhD, MD Centre de Recherche en Nutrition Humaine Rhône-Alpes
  More Information

Publications automatically indexed to this study by Identifier (NCT Number):
Responsible Party: Martine Laville PhD, MD, CRNHRA Identifier: NCT00905892     History of Changes
Other Study ID Numbers: CRNHRA-09-002
Study First Received: May 20, 2009
Last Updated: June 22, 2011

Keywords provided by Centre de Recherche en Nutrition Humaine Rhone-Alpe:
stable isotopes
lipoprotein metabolism
lipid oxidation
fat distribution
gene expression
mass spectrometry/gas chromatography

Additional relevant MeSH terms:
Pathologic Processes processed this record on April 28, 2017