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Effects of Physical Training on Heart Rate Variability and Exercise Capacity in Diabetes With Autonomic Neuropathy

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ClinicalTrials.gov Identifier: NCT00904761
Recruitment Status : Completed
First Posted : May 20, 2009
Last Update Posted : December 28, 2012
Sponsor:
Information provided by (Responsible Party):
National Taiwan University Hospital

Brief Summary:
This study aimed to investigate effects of physical training on exercise capacity and changes of heart rate variability (HRV) at rest, during exercise, and post-exercise in the patient with diabetes with autonomic neuropathy (DAN).

Condition or disease Intervention/treatment Phase
Diabetes Mellitus Other: exercise training Not Applicable

Study Type : Interventional  (Clinical Trial)
Allocation: Non-Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)
Official Title: Effects of Physical Training on Heart Rate Variability and Exercise Capacity in Diabetes With Autonomic Neuropathy
Study Start Date : October 2001
Actual Primary Completion Date : May 2002
Actual Study Completion Date : May 2002

Resource links provided by the National Library of Medicine


Arm Intervention/treatment
Experimental: exercise
arm: intervention
Other: exercise training
The exercise group took supervised aerobic training twice per week at hospital and thrice per week at home for eight weeks at the intensity of 60-70% VO2peak




Primary Outcome Measures :
  1. heart rate variability [ Time Frame: 8 weeks ]
  2. exercise capacity [ Time Frame: 8 weeks ]


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Ages Eligible for Study:   20 Years to 65 Years   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Criteria

Inclusion Criteria:

  • aged under 65 years old
  • receiving regular treatment
  • HbA1c < 8.0
  • decreased HR response in deep breathing maneuver

Exclusion Criteria:

  • heart disease
  • neuro-musculo-skeletal diseases
  • taking any medication that may affect HRV (such as α or β-blockers)

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00904761


Locations
Taiwan
National Taiwan University Hospital
Taipei, Taiwan, 100
Sponsors and Collaborators
National Taiwan University Hospital
Investigators
Study Director: Ying-Tai Wu, Doctor National Taiwan University Hospital

Responsible Party: National Taiwan University Hospital
ClinicalTrials.gov Identifier: NCT00904761     History of Changes
Other Study ID Numbers: 25670
First Posted: May 20, 2009    Key Record Dates
Last Update Posted: December 28, 2012
Last Verified: November 2012

Keywords provided by National Taiwan University Hospital:
diabetes mellitus
autonomic neuropathy
exercise training
exercise capacity
heart rate variability

Additional relevant MeSH terms:
Diabetes Mellitus
Nervous System Diseases
Glucose Metabolism Disorders
Metabolic Diseases
Endocrine System Diseases