Try our beta test site
IMPORTANT: Listing of a study on this site does not reflect endorsement by the National Institutes of Health. Talk with a trusted healthcare professional before volunteering for a study. Read more...

Effects of Physical Training on Heart Rate Variability and Exercise Capacity in Diabetes With Autonomic Neuropathy

This study has been completed.
Information provided by (Responsible Party):
National Taiwan University Hospital Identifier:
First received: May 18, 2009
Last updated: December 27, 2012
Last verified: November 2012
This study aimed to investigate effects of physical training on exercise capacity and changes of heart rate variability (HRV) at rest, during exercise, and post-exercise in the patient with diabetes with autonomic neuropathy (DAN).

Condition Intervention
Diabetes Mellitus
Other: exercise training

Study Type: Interventional
Study Design: Allocation: Non-Randomized
Intervention Model: Parallel Assignment
Masking: Open Label
Official Title: Effects of Physical Training on Heart Rate Variability and Exercise Capacity in Diabetes With Autonomic Neuropathy

Resource links provided by NLM:

Further study details as provided by National Taiwan University Hospital:

Primary Outcome Measures:
  • heart rate variability [ Time Frame: 8 weeks ]
  • exercise capacity [ Time Frame: 8 weeks ]

Study Start Date: October 2001
Study Completion Date: May 2002
Primary Completion Date: May 2002 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Experimental: exercise
arm: intervention
Other: exercise training
The exercise group took supervised aerobic training twice per week at hospital and thrice per week at home for eight weeks at the intensity of 60-70% VO2peak


Ages Eligible for Study:   20 Years to 65 Years   (Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No

Inclusion Criteria:

  • aged under 65 years old
  • receiving regular treatment
  • HbA1c < 8.0
  • decreased HR response in deep breathing maneuver

Exclusion Criteria:

  • heart disease
  • neuro-musculo-skeletal diseases
  • taking any medication that may affect HRV (such as α or β-blockers)
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its identifier: NCT00904761

National Taiwan University Hospital
Taipei, Taiwan, 100
Sponsors and Collaborators
National Taiwan University Hospital
Study Director: Ying-Tai Wu, Doctor National Taiwan University Hospital
  More Information

Responsible Party: National Taiwan University Hospital Identifier: NCT00904761     History of Changes
Other Study ID Numbers: 25670
Study First Received: May 18, 2009
Last Updated: December 27, 2012

Keywords provided by National Taiwan University Hospital:
diabetes mellitus
autonomic neuropathy
exercise training
exercise capacity
heart rate variability

Additional relevant MeSH terms:
Diabetes Mellitus
Nervous System Diseases
Glucose Metabolism Disorders
Metabolic Diseases
Endocrine System Diseases processed this record on May 25, 2017