Effect of Arginine on Microcirculation in Patients With Diabetes
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Patients with diabetes have dysfunction of the lining of the arteries which lead to impaired circulation in the small blood vessels. This is thought to be secondary to reduced chemicals in the blood viz: nitric oxide. This chemical is derived from an amino acid (protein) L-arginine. Therefore, the researchers investigated whether giving patients L-arginine (versus dummy powder) would improve the blood flow in the small blood vessels in the lower limbs of patients with damage to their nerves (neuropathy).
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Ages Eligible for Study:
30 Years to 65 Years (Adult)
Sexes Eligible for Study:
Accepts Healthy Volunteers:
Males and females diabetic patients with peripheral neuropathy, aged 30-65 years
Type 2 diabetes (NIDDM) judged by WHO criteria:
onset of diabetes mellitus after the age of 30 years
not requiring insulin for control of diabetes or insulin treatment initiated after one year diagnosis of diabetes
no history of diabetic ketoacidosis
All patients will have detailed history and physical examination
Patients with ischaemic heart disease
Previous stroke and severe peripheral vascular disease)
Renal failure (defined as serum creatinine > 120 mmol/l)