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Study to Compare Standard Perimetry With the New Scotoma-Oriented Perimetry (SCOPE) Using a New Fast German Adaptive Threshold Estimation (GATE) in Glaucoma Patients (TRASCO)

This study is ongoing, but not recruiting participants.
Alcon Research
Information provided by (Responsible Party):
Ulrich Schiefer, University Hospital Tuebingen Identifier:
First received: May 12, 2009
Last updated: January 31, 2016
Last verified: January 2016
The purpose of this study is to compare the two psychophysical perimetric techniques regarding progression of the visual field.

Condition Intervention
Primary Open Angle Glaucoma (POAG)
Device: Perimetry
Device: Confocal Scanning Laser Tomography
Device: Optical Coherence Tomography (OCT)

Study Type: Observational
Study Design: Observational Model: Cohort
Time Perspective: Prospective
Official Title: Pilot Study to Compare the Humphrey Field Analyzer (HFA) 30-2 Swedish Interactive Threshold Algorithm (SITA) Standard Perimetry With the New Scotoma-Oriented Perimetry (SCOPE), Using a New Fast GATE (German Adaptive Threshold Estimation) in Glaucoma Patients Under Topic Therapy

Resource links provided by NLM:

Further study details as provided by University Hospital Tuebingen:

Primary Outcome Measures:
  • Comparison of rate of progression [ Time Frame: 36 month ]
    Perimetric measures every 3 month over 3 years

Estimated Enrollment: 12
Study Start Date: April 2010
Estimated Study Completion Date: December 2016
Estimated Primary Completion Date: December 2016 (Final data collection date for primary outcome measure)
Groups/Cohorts Assigned Interventions
perimetry, HRT, OCT
perimetry, HRT, OCT
Device: Perimetry
different perimetric devices, different perimetric grids: Octopus: New Scotoma-Oriented Perimetry (SCOPE) Using a New Fast German Adaptive Threshold Estimation (GATE) HFA: 30-2, Sita (Swedish Interactive Thresholding Algorithm) full threshold
Other Name: Humphrey Field Analyzer 745i (HFA), Interzeag Octopus 101
Device: Confocal Scanning Laser Tomography
HRT examinations for the clinical evaluation of the optic disc.
Other Name: Heidelberg Retina Tomograph (HRT)
Device: Optical Coherence Tomography (OCT)
imaging of the retinal nerve fiber layer
Other Name: Spectralis-OCT (Heidelberg Engineering, Heidelberg, Germany)


Ages Eligible for Study:   18 Years and older   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Probability Sample
Study Population
University Eye Hospital

Inclusion Criteria:

  • primary open angle glaucoma (POAG)
  • spherical ametropia max. ± 8 dpt
  • cylindrical ametropia max. ± 3 dpt
  • distant visual acuity > 10/20
  • pupil diameter > 3 mm

Exclusion Criteria:

  • diabetic retinopathy
  • asthma
  • history of epilepsy or significant psychiatric disease
  • medications known to effect visual field sensitivity
  • infections (e.g., keratitis, conjunctivitis, uveitis)
  • severe dry eyes
  • miotic drug
  • squint
  • nystagmus
  • albinism
  • any ocular pathology, in either eye, that may interfere with the ability to obtain visual fields
  • keratoconus
  • intraocular surgery (except for uncomplicated cataract surgery) performed < 3 month prior to screening
  • history or signs of any visual pathway affection other than glaucoma
  • history or presence of macular disease and/or macular edema, ocular trauma, medications known to affect visual field sensitivity
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Please refer to this study by its identifier: NCT00902109

Institute for Ophthalmic Research
Tuebingen, Germany, 72076
Sponsors and Collaborators
University Hospital Tuebingen
Alcon Research
Principal Investigator: Ulrich Schiefer, Prof. Dr. med. University Hospital Tuebingen
  More Information

Responsible Party: Ulrich Schiefer, Prof. Dr. med., University Hospital Tuebingen Identifier: NCT00902109     History of Changes
Other Study ID Numbers: SCOPE-G-BETA
Study First Received: May 12, 2009
Last Updated: January 31, 2016

Keywords provided by University Hospital Tuebingen:
visual field

Additional relevant MeSH terms:
Glaucoma, Open-Angle
Ocular Hypertension
Eye Diseases
Vision Disorders
Sensation Disorders
Neurologic Manifestations
Nervous System Diseases
Signs and Symptoms processed this record on May 24, 2017