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Marine n-3 Polyunsaturated Fatty Acids in Pre- and Postmenopausal Women

This study has been completed.
Information provided by:
Aalborg Universitetshospital Identifier:
First received: May 13, 2009
Last updated: NA
Last verified: May 2009
History: No changes posted
The study is a randomised placebo controlled double-blinded clinical trial where a group of healthy pre- and postmenopausal women is randomised to the intake of fish oil capsules or placebo oil capsules for 12 weeks. Anthropometric measurements(weight, height,blood pressure) blood samples and adipose tissue biopsies will be taken in order to illustrate the effect of marine n-3 PUFAs (fish oil) on the concentration of circulating female hormones and to investigate what impact menopause might have on the ability to incorporate marine n-3 PUFAs into tissues.

Condition Intervention
Dietary Supplement: marine n-3 polyunsaturated fatty acids
Dietary Supplement: thistle oil
Dietary Supplement: Thistle oil

Study Type: Interventional
Study Design: Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Double Blind (Participant, Care Provider, Investigator, Outcomes Assessor)
Primary Purpose: Basic Science
Official Title: The Incorporation of Marine n-3 Polyunsaturated Fatty Acids in Pre- and Postmenopausal Women: a Randomized Double-Blinded Placebo-Controlled Clinical Trial

Resource links provided by NLM:

Further study details as provided by Aalborg Universitetshospital:

Primary Outcome Measures:
  • Content of marine n-PUFAs as percent of total content of fatty acids in adipose tissue and in platelets before and after intervention

Secondary Outcome Measures:
  • Measurement of oestrogen concentrations in blood before and after intervention

Enrollment: 92
Study Start Date: August 2007
Study Completion Date: May 2009
Primary Completion Date: May 2009 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Active Comparator: Premenopausal women-fishoil Dietary Supplement: marine n-3 polyunsaturated fatty acids
Four capsules daily containing 2.2 g marine n-3 polyunsaturated fatty acids in total
Other Name: Fish oil
Placebo Comparator: Premenopausal-placebo Dietary Supplement: thistle oil
four capsules a day
Active Comparator: Postmenopausal women-fishoil Dietary Supplement: marine n-3 polyunsaturated fatty acids
Four capsules daily, 2.2 g marine n-3 PUFAs in total
Other Name: Fish oil
Placebo Comparator: Postmenopausal-placebo Dietary Supplement: Thistle oil
Four capsules daily


Ages Eligible for Study:   18 Years to 70 Years   (Adult, Senior)
Sexes Eligible for Study:   Female
Accepts Healthy Volunteers:   Yes

Inclusion Criteria:

  • age 18-70 years old
  • healthy or well-treated chronic disease

Exclusion Criteria:

  • hormone treatment
  • foreseen compliance problem
  • fish oil consumers
  Contacts and Locations
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Please refer to this study by its identifier: NCT00901589

Center for cardiovascular research, Aalborg Hospital
Aalborg, Denmark, 9000
Sponsors and Collaborators
Aalborg Universitetshospital
  More Information

Responsible Party: Dr., ph.d.stud. Petra Witt Identifier: NCT00901589     History of Changes
Other Study ID Numbers: Petra Witt
Study First Received: May 13, 2009
Last Updated: May 13, 2009

Keywords provided by Aalborg Universitetshospital:
n-3 PUFAs
adipose tissue
Incorporation of fishoil in pre- and postmenopausal women
Marine n-3 PUFAs influence on female hormones in blood processed this record on May 25, 2017